Advances in development of new treatment for leishmaniasis
JPB de Menezes, CES Guedes… - BioMed research …, 2015 - Wiley Online Library
Leishmaniasis is a neglected infectious disease caused by several different species of
protozoan parasites of the genus Leishmania. Current strategies to control this disease are …
protozoan parasites of the genus Leishmania. Current strategies to control this disease are …
Proteomics of trypanosomatids of human medical importance
Leishmania spp., Trypanosoma cruzi, and Trypanosoma brucei are protozoan parasites that
cause a spectrum of fatal human diseases around the world. Recent completion of the …
cause a spectrum of fatal human diseases around the world. Recent completion of the …
Proteomic characterization of the released/secreted proteins of Leishmania (Viannia) braziliensis promastigotes
P Cuervo, JB De Jesus, L Saboia-Vahia… - Journal of …, 2009 - Elsevier
Extracellular proteins secreted/released by protozoan parasites are key mediators of the
host–parasite interaction. To characterise the profile of proteins secreted/released by …
host–parasite interaction. To characterise the profile of proteins secreted/released by …
Proteins selected in Leishmania (Viannia) braziliensis by an immunoproteomic approach with potential serodiagnosis applications for tegumentary leishmaniasis
MC Duarte, DC Pimenta… - Clinical and Vaccine …, 2015 - Am Soc Microbiol
The serodiagnosis of human tegumentary leishmaniasis (TL) presents some problems, such
as the low level of antileishmanial antibodies found in most of the patients, as well as the …
as the low level of antileishmanial antibodies found in most of the patients, as well as the …
Analysis of Leishmania chagasi by 2-D Difference Gel Eletrophoresis (2-D DIGE) and Immunoproteomic: Identification of Novel Candidate Antigens for Diagnostic …
MM Costa, HM Andrade, DC Bartholomeu… - Journal of proteome …, 2011 - ACS Publications
Identification of novel antigens is essential for developing new diagnostic tests and
vaccines. We used DIGE to compare protein expression in amastigote and promastigote …
vaccines. We used DIGE to compare protein expression in amastigote and promastigote …
Proteome mapping of overexpressed membrane‐enriched and cytosolic proteins in sodium antimony gluconate (SAG) resistant clinical isolate of Leishmania …
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Over 60% of patients with visceral
leishmaniasis (VL) in India and Sudan have become unresponsive to treatment with …
leishmaniasis (VL) in India and Sudan have become unresponsive to treatment with …
Contribution of proteomics of Leishmania spp. to the understanding of differentiation, drug resistance mechanisms, vaccine and drug development
D Paape, T Aebischer - Journal of proteomics, 2011 - Elsevier
Leishmania spp., protozoan parasites with a digenetic life cycle, cause a spectrum of
diseases in humans. Recently several Leishmania spp. have been sequenced which …
diseases in humans. Recently several Leishmania spp. have been sequenced which …
In-depth quantitative proteomics uncovers specie-specific metabolic programs in Leishmania (Viannia) species
N Pinho, JR Wiśniewski, G Dias-Lopes… - PLoS neglected …, 2020 - journals.plos.org
Leishmania species are responsible for a broad spectrum of diseases, denominated
Leishmaniasis, affecting over 12 million people worldwide. During the last decade, there …
Leishmaniasis, affecting over 12 million people worldwide. During the last decade, there …
Omics approaches in drug development against leishmaniasis: Current scenario and future prospects
AA Rabaan, MA Bakhrebah, RK Mohapatra… - Pathogens, 2022 - mdpi.com
Leishmaniasis is a zoonotic disease transmitted in humans by the bite of Leishmania-
infected phlebotomine sandflies. Each year approximately 58,500 cases of leishmaniasis …
infected phlebotomine sandflies. Each year approximately 58,500 cases of leishmaniasis …
Proteomic analysis reveals differentially abundant proteins probably involved in the virulence of amastigote and promastigote forms of Leishmania infantum
L Fialho Junior, S da Fonseca Pires, R Burchmore… - Parasitology …, 2021 - Springer
Owing to the importance and clinical diversity of Leishmania infantum, studying its virulence
factors is promising for understanding the relationship between parasites and hosts. In the …
factors is promising for understanding the relationship between parasites and hosts. In the …