[HTML][HTML] Molecular pharmacology of synthetic cannabinoids: delineating CB1 receptor-mediated cell signaling

KB Walsh, HK Andersen - International journal of molecular sciences, 2020 - mdpi.com
Synthetic cannabinoids (SCs) are a class of new psychoactive substances (NPSs) that
exhibit high affinity binding to the cannabinoid CB1 and CB2 receptors and display a …

Sample preparation and instrumental methods for illicit drugs in environmental and biological samples: A review

X Chen, X Wu, T Luan, R Jiang, G Ouyang - Journal of Chromatography A, 2021 - Elsevier
Detection of illicit drugs in the environmental samples has been challenged as the
consumption increases globally. Current review examines the recent developments and …

Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL …

A Cannaert, E Sparkes, E Pike, JL Luo… - ACS Chemical …, 2020 - ACS Publications
Synthetic cannabinoid receptor agonists (SCRAs) are an evolving class of new psychoactive
substances (NPS) with structurally diverse compounds emerging each year. Due to the rapid …

Detection and quantitation of synthetic cannabinoid receptor agonists in infused papers from prisons in a constantly evolving illicit market

C Norman, G Walker, B McKirdy… - Drug Testing and …, 2020 - Wiley Online Library
Drug misuse in prisons contributes to increased disruption and violence and negatively
impacts prisoner safety, rehabilitation, and recovery. Synthetic cannabinoid receptor …

The metabolism of the synthetic cannabinoids ADB‐BUTINACA and ADB‐4en‐PINACA and their detection in forensic toxicology casework and infused papers seized …

R Kronstrand, C Norman, S Vikingsson… - Drug Testing and …, 2022 - Wiley Online Library
Early warning systems detect new psychoactive substances (NPS), while dedicated
monitoring programs and routine drug and toxicology testing identify fluctuations in …

The next generation of synthetic cannabinoids: Detection, activity, and potential toxicity of pent‐4en and but‐3en analogues including MDMB‐4en‐PINACA

AJ Krotulski, A Cannaert, C Stove… - Drug testing and …, 2021 - Wiley Online Library
A new class of synthetic cannabinoids has emerged as new psychoactive substances
(NPS). Similar in structure to JWH‐022, these substances contain alkene modifications to …

Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists

E Wouters, J Walraed, SD Banister, CP Stove - Biochemical pharmacology, 2019 - Elsevier
Abstract Cannabinoid receptors type 1 (CB 1) and type 2 (CB 2) are promising targets for a
number of diseases, including obesity, neuropathic pain, and multiple sclerosis, among …

Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB‐4en‐PICA, MDMB‐4en‐PINACA, ADB‐4en‐PINACA, and …

KE Grafinger, MM Vandeputte… - Drug testing and …, 2021 - Wiley Online Library
The present work is the last of a three‐part study investigating a panel of 30 systematically
designed synthetic cannabinoid receptor agonists (SCRAs) including features such as the 4 …

[HTML][HTML] Separation of enantiomers and positional isomers of novel psychoactive substances in solid samples by chromatographic and electrophoretic techniques–A …

MG Schmid, JS Hägele - Journal of Chromatography A, 2020 - Elsevier
Abstract Novel Psychoactive Substances (NPS) represent an alternative to established illicit
drugs. They are traded via the internet and exhibit small alterations in their chemical …

Do toxic synthetic cannabinoid receptor agonists have signature in vitro activity profiles? A case study of AMB-FUBINACA

DB Finlay, JJ Manning, MS Ibsen… - ACS chemical …, 2019 - ACS Publications
Recreational consumption of synthetic cannabinoid receptor agonists (SCRAs) is a growing
crisis in public health in many parts of the world. AMB-FUBINACA is a member of this class …