Abstract Histone–lysine N-methyltransferase 2 (KMT2) family proteins methylate lysine 4 on
the histone H3 tail at important regulatory regions in the genome and thereby impart crucial …

Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …

Flavonoids are secondary metabolites involved in several aspects of plant development and
defence. They colour fruits and flowers, favouring seed and pollen dispersal, and contribute …

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight
different classes have been characterized to date and many different sites have been …

An important development in understanding the influence of chromatin on gene regulation
has been the finding that DNA methylation and histone post-translational modifications lead …

The WD40 domain exhibits a β-propeller architecture, often comprising seven blades. The
WD40 domain is one of the most abundant domains and also among the top interacting …

The covalent marking of proteins by methyl group addition to arginine residues can promote
their recognition by binding partners or can modulate their biological activity. A small family …

Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group
of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA …

Histones comprise the major protein component of chromatin, the scaffold in which the
eukaryotic genome is packaged, and are subject to many types of post-translational …

Recent findings indicate that WD40 domains play central roles in biological processes by
acting as hubs in cellular networks; however, they have been studied less intensely than …