Antioxidative and anti-inflammatory properties of cannabidiol
S Atalay, I Jarocka-Karpowicz, E Skrzydlewska - Antioxidants, 2019 - mdpi.com
Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …
New approaches and challenges to targeting the endocannabinoid system
V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …
discovery of several promising drug targets and novel therapeutic strategies to address the …
The effects of cannabidiol, a non-intoxicating compound of cannabis, on the cardiovascular system in health and disease
A Kicman, M Toczek - International journal of molecular sciences, 2020 - mdpi.com
Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis
which exhibits potential beneficial properties in a wide range of diseases, including …
which exhibits potential beneficial properties in a wide range of diseases, including …
Cannabidiol prevents LPS‐induced microglial inflammation by inhibiting ROS/NF‐κB‐dependent signaling and glucose consumption
M dos‐Santos‐Pereira, FS Guimaraes, E Del‐Bel… - Glia, 2020 - Wiley Online Library
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to
study the anti‐inflammatory potential of cannabidiol (CBD), the major nonpsychoactive …
study the anti‐inflammatory potential of cannabidiol (CBD), the major nonpsychoactive …
G protein–coupled receptors targeting insulin resistance, obesity, and type 2 diabetes mellitus
G protein–coupled receptors (GPCRs) continue to be important discovery targets for the
treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the …
treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the …
The expanded endocannabinoid system/endocannabinoidome as a potential target for treating diabetes mellitus
Abstract Purpose of Review The endocannabinoid (eCB) system, ie the receptors that
respond to the psychoactive component of cannabis, their endogenous ligands and the …
respond to the psychoactive component of cannabis, their endogenous ligands and the …
Advances in the physiology of GPR55 in the central nervous system
BA Marichal-Cancino, A Fajardo-Valdez… - Current …, 2017 - ingentaconnect.com
Background: The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor
that awaits a formal classification. There are an increasing number of reports directed to …
that awaits a formal classification. There are an increasing number of reports directed to …
Human CB1 receptor isoforms, present in hepatocytes and β-cells, are involved in regulating metabolism
I González-Mariscal, SM Krzysik-Walker, ME Doyle… - Scientific reports, 2016 - nature.com
Therapeutics aimed at blocking the cannabinoid 1 (CB1) receptor for treatment of obesity
resulted in significant improvements in liver function, glucose uptake and pancreatic β-cell …
resulted in significant improvements in liver function, glucose uptake and pancreatic β-cell …
The therapeutic potential of orphan GPCRs, GPR35 and GPR55
DM Shore, PH Reggio - Frontiers in pharmacology, 2015 - frontiersin.org
The G protein-coupled receptor (GPCR) superfamily of integral proteins is the largest family
of signal transducers, comprised of∼ 1000 members. Considering their prevalence and …
of signal transducers, comprised of∼ 1000 members. Considering their prevalence and …