Cannabidiol (CBD) is one of the main pharmacologically active phytocannabinoids of
Cannabis sativa L. CBD is non-psychoactive but exerts a number of beneficial …

The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis
which exhibits potential beneficial properties in a wide range of diseases, including …

We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to
study the anti‐inflammatory potential of cannabidiol (CBD), the major nonpsychoactive …

G protein–coupled receptors (GPCRs) continue to be important discovery targets for the
treatment of type 2 diabetes mellitus (T2DM). Many GPCRs are directly involved in the …

Abstract Purpose of Review The endocannabinoid (eCB) system, ie the receptors that
respond to the psychoactive component of cannabis, their endogenous ligands and the …

Background: The G protein-coupled receptor 55 (GPR55) is a mammalian orphan receptor
that awaits a formal classification. There are an increasing number of reports directed to …

Therapeutics aimed at blocking the cannabinoid 1 (CB1) receptor for treatment of obesity
resulted in significant improvements in liver function, glucose uptake and pancreatic β-cell …

The G protein-coupled receptor (GPCR) superfamily of integral proteins is the largest family
of signal transducers, comprised of∼ 1000 members. Considering their prevalence and …