Biological barriers are essential for the maintenance of homeostasis in health and disease.
Breakdown of the intestinal barrier is an essential aspect of the pathophysiology of …

Various subgroups of CD8+ T lymphocytes do not only demonstrate cytotoxic effects, but
also serve important regulatory roles in the body's immune response. In particular, CD8+ …

Human mucosal associated invariant T (MAIT) CD8+ and Tc17 cells are important tissue-
homing cell populations, characterized by high expression of CD161 (++) and type-17 …

The role of interferon (IFN)-γ in multiple sclerosis (MS) and its animal model, experimental
autoimmune encephalomyelitis (EAE), has remained as an enigmatic paradox for more than …

Regulatory T cells (Tregs) play a key role in the peripheral self‐tolerance and preventing
autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ …

Despite their first recognition almost 40 years ago, CD8+'suppressor'T cells remain poorly
characterized. Recent studies of these lymphocytes, now popularly referred to as regulatory …

In this review, we first revisit the original concept of “suppressor T-cells” in pregnancy, put it
in a historical perspective, and then highlight the main data that licensed its resurrection and …

Objective The objective of this study was to investigate the role of CD8+ CD25+ FoxP3+
cells during the course of multiple sclerosis (MS). Methods Peripheral blood and …

Regulatory T cells (Tregs), in particular CD4+ Foxp3+ T cells, have been shown to play an
important role in the maintenance of tolerance after allogeneic stem cell transplantation. In …

Abstract “Suppressor T cells” were historically defined within the CD8+ T‐cell compartment
and recent studies have highlighted several naturally occurring CD8+ Foxp3− Treg …