Abstract BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases
originating from a single hematopoietic stem cell that cause excessive production of mature …

Stem-Cell Aging and Pathways to Precancer Evolution | New England Journal of Medicine Skip
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The classic Philadelphia chromosome–negative myeloproliferative neoplasms (MPN)
consist of myelofibrosis, polycythemia vera, and essential thrombocythemia and are a …

Some cancers originate from a single mutation event in a single cell. Blood cancers known
as myeloproliferative neoplasms (MPNs) are thought to originate when a driver mutation is …

Background Cancers arise from multiple acquired mutations, which presumably occur over
many years. Early stages in cancer development might be present years before cancers …

Genomic studies have identified somatic alterations in the majority of myeloproliferative
neoplasms (MPN) patients, including JAK2 mutations in the majority of MPN patients and …

Background The myelodysplastic syndromes and myeloproliferative disorders are
associated with deregulated production of myeloid cells. The mechanisms underlying these …

Constitutive JAK2 activation in hematopoietic cells by the JAK2V617F mutation recapitulates
myeloproliferative neoplasm (MPN) phenotypes in mice, establishing JAK2 inhibition as a …

Background The V617F mutation, which causes the substitution of phenylalanine for valine
at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with …

The limited vessel-forming capacity of infused endothelial progenitor cells (EPCs) into
patients with cardiovascular dysfunction may be related to a misunderstanding of the …