[HTML][HTML] Genetic architecture of gene expression in European and African Americans: an eQTL mapping study in GENOA
Most existing expression quantitative trait locus (eQTL) mapping studies have been focused
on individuals of European ancestry and are underrepresented in other populations …
on individuals of European ancestry and are underrepresented in other populations …
[HTML][HTML] Multi-omic approaches to identify genetic factors in metabolic syndrome
KC Clark, AE Kwitek - Comprehensive Physiology, 2021 - ncbi.nlm.nih.gov
Abstract Metabolic Syndrome (MetS) is a highly heritable disease and a major public health
burden worldwide. MetS diagnosis criteria is met by the simultaneous presence of any three …
burden worldwide. MetS diagnosis criteria is met by the simultaneous presence of any three …
Our tangled family tree: new genomic methods offer insight into the legacy of archaic admixture
The archaic ancestry present in the human genome has captured the imagination of both
scientists and the wider public in recent years. This excitement is the result of new studies …
scientists and the wider public in recent years. This excitement is the result of new studies …
Lifestyle factors and genetic variants on 2 biological age measures: evidence from 94 443 taiwan biobank participants
WY Lin - The Journals of Gerontology: Series A, 2022 - academic.oup.com
Background Biological age (BA) can be estimated by phenotypes and is useful for predicting
life span and health span. Levine et al. proposed a PhenoAge and a BioAge to measure BA …
life span and health span. Levine et al. proposed a PhenoAge and a BioAge to measure BA …
[HTML][HTML] Protein prediction for trait mapping in diverse populations
R Schubert, E Geoffroy, I Gregga, AJ Mulford, F Aguet… - PLoS …, 2022 - journals.plos.org
Genetically regulated gene expression has helped elucidate the biological mechanisms
underlying complex traits. Improved high-throughput technology allows similar interrogation …
underlying complex traits. Improved high-throughput technology allows similar interrogation …
[HTML][HTML] On the cross-population generalizability of gene expression prediction models
The genetic control of gene expression is a core component of human physiology. For the
past several years, transcriptome-wide association studies have leveraged large datasets of …
past several years, transcriptome-wide association studies have leveraged large datasets of …
[HTML][HTML] Transcriptome prediction performance across machine learning models and diverse ancestries
Transcriptome prediction methods such as PrediXcan and FUSION have become popular in
complex trait mapping. Most transcriptome prediction models have been trained in …
complex trait mapping. Most transcriptome prediction models have been trained in …
[HTML][HTML] A multi-tissue transcriptome analysis of human metabolites guides interpretability of associations based on multi-SNP models for gene expression
There is particular interest in transcriptome-wide association studies (TWAS) gene-level
tests based on multi-SNP predictive models of gene expression—for identifying causal …
tests based on multi-SNP predictive models of gene expression—for identifying causal …
[HTML][HTML] Multivariate adaptive shrinkage improves cross-population transcriptome prediction and association studies in underrepresented populations
Transcriptome prediction models built with data from European-descent individuals are less
accurate when applied to different populations because of differences in linkage …
accurate when applied to different populations because of differences in linkage …
[HTML][HTML] A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility
G Voloudakis, JM Vicari, S Venkatesh… - NPJ Genomic …, 2022 - nature.com
Recent efforts have identified genetic loci that are associated with coronavirus disease 2019
(COVID-19) infection rates and disease outcome severity. Translating these genetic findings …
(COVID-19) infection rates and disease outcome severity. Translating these genetic findings …