Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality
amongst civilians and military personnel globally. Despite advances in our knowledge of the …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

The Rho family of GTPases belongs to the Ras superfamily of low molecular weight (∼ 21
kDa) guanine nucleotide binding proteins. The most extensively studied members are RhoA …

Rho kinase (ROCK) is a serine/threonine kinase and a downstream target of the small
GTPase Rho. The RhoA/ROCK pathway is associated with various neuronal functions such …

Neuronal networks, especially those in the central nervous system (CNS), evolved to
support extensive functional capabilities while ensuring stability. Several physiological …

Bacterial ADP-ribosyltransferase toxins (bARTTs) transfer ADP-ribose to eukaryotic proteins
to promote bacterial pathogenesis. In this Review, we use prototype bARTTs, such as …

Abstract The Rho/ROCK/LIMK pathway is central for the mediation of repulsive
environmental signals in the central nervous system. Several studies using pharmacological …

Ischemic strokes (IS) and spinal cord injuries (SCI) are major causes of disability. RhoA is a
small GTPase protein that activates a downstream effector, ROCK. The up-regulation of the …

Traumatic spinal cord injury (SCI) is a devastating condition of motor, sensory, and
autonomic dysfunction. The significant cost associated with the management and lifetime …

Background The Rho pathway has been shown to have a role in the pathophysiology of
spinal cord injury (SCI). Upregulation of the Rho signaling pathway occurs as a result of SCI …