8-Hydroxyquinolines in medicinal chemistry: A structural perspective
V Oliveri, G Vecchio - European journal of medicinal chemistry, 2016 - Elsevier
Hydroxyquinolines are heterocyclic compounds characterized by a moderate metal-binding
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …
affinity. The interest in 8-hydroxyquinolines has grown exponentially in the last two decades …
Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry
Hydroxyquinoline (8-HQ) is a significant heterocyclic scaffold in organic and analytical
chemistry because of the properties of chromophore and is used to detect various metal ions …
chemistry because of the properties of chromophore and is used to detect various metal ions …
The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors
A Pišlar, A Mitrović, J Sabotič, U Pečar Fonović… - PLoS …, 2020 - journals.plos.org
Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into
humans, causing highly prevalent and severe respiratory diseases, often with fatal …
humans, causing highly prevalent and severe respiratory diseases, often with fatal …
Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …
[HTML][HTML] Recent advances in drug repositioning for the discovery of new anticancer drugs
Drug repositioning (also referred to as drug repurposing), the process of finding new uses of
existing drugs, has been gaining popularity in recent years. The availability of several …
existing drugs, has been gaining popularity in recent years. The availability of several …
New drugs are not enough-drug repositioning in oncology: An update
RG Armando, DLM Gomez… - … Journal of Oncology, 2020 - spandidos-publications.com
Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …
are already known for use treating other diseases. The advantages of this are that several …
Engineering at the nano-bio interface: harnessing the protein corona towards nanoparticle design and function
Unpredictable and uncontrollable protein adsorption on nanoparticles remains a
considerable challenge to achieving effective application of nanotechnologies within …
considerable challenge to achieving effective application of nanotechnologies within …
Chelation in antibacterial drugs: From nitroxoline to cefiderocol and beyond
In the era of escalating antimicrobial resistance, the need for antibacterial drugs with novel
or improved modes of action (MOAs) is a health concern of utmost importance. Adding or …
or improved modes of action (MOAs) is a health concern of utmost importance. Adding or …
The current stage of cathepsin B inhibitors as potential anticancer agents
J Kos, A Mitrović, B Mirković - Future medicinal chemistry, 2014 - Taylor & Francis
Cathepsin B is a lysosomal cysteine peptidase, with an important role in the development
and progression of cancer. It is involved in the degradation of extracellular matrix proteins, a …
and progression of cancer. It is involved in the degradation of extracellular matrix proteins, a …
[HTML][HTML] Targeting cathepsin B for cancer therapies
Cathepsin B is a member of the papain family of cysteine proteases normally present in the
lysosome, but it can translocate and function to degrade components of the extracellular …
lysosome, but it can translocate and function to degrade components of the extracellular …