Dopamine in the regulation of glucose homeostasis, pathogenesis of type 2 diabetes, and chronic conditions of impaired dopamine activity/metabolism: Implication for …

G Lisco, A De Tullio, M Iovino, O Disoteo… - Biomedicines, 2023 - mdpi.com
Dopamine regulates several functions, such as voluntary movements, spatial memory,
motivation, sleep, arousal, feeding, immune function, maternal behaviors, and lactation …

Roles of pancreatic islet catecholamine neurotransmitters in glycemic control and in antipsychotic drug–induced dysglycemia

Z Freyberg, GK Gittes - Diabetes, 2023 - Am Diabetes Assoc
Catecholamine neurotransmitters dopamine (DA) and norepinephrine (NE) are essential for
a myriad of functions throughout the central nervous system, including metabolic regulation …

Structural and expression analysis of the dopamine receptors reveals their crucial roles in regulating the insulin signaling pathway in oysters

Y Li, Y Tan, L Ren, Q Li, J Sui, S Liu - International Journal of Biological …, 2023 - Elsevier
Dopamine performs its critical role upon binding to receptors. Since dopamine receptors are
numerous and versatile, understanding their protein structures and evolution status, and …

Activation of Multiple G Protein Pathways to Characterize the Five Dopamine Receptor Subtypes Using Bioluminescence Technology

D Mönnich, LJ Humphrys, C Höring… - ACS Pharmacology & …, 2024 - ACS Publications
G protein-coupled receptors show preference for G protein subtypes but can recruit multiple
G proteins with various downstream signaling cascades. This functional selection can guide …

Evidence for dopamine production and distribution of dopamine D2 receptors in the equine gastrointestinal mucosa and pancreas

NC Galinelli, NJ Bamford, MA de Laat, MN Sillence… - Plos one, 2024 - journals.plos.org
Insulin dysregulation in horses is characterised by hyperinsulinaemia and/or tissue insulin
resistance and is associated with increased risk of laminitis. There is growing evidence in …

[HTML][HTML] Dopamine-Mediated Autocrine Inhibition of Insulin Secretion

E Ferrero, M Masini, M Carli, S Moscato, P Beffy… - Molecular and Cellular …, 2024 - Elsevier
The aim of the present research was to explore the mechanisms underlying the role of
dopamine in the regulation of insulin secretion in beta cells. The effect of dopamine on …

Dopamine signalling in pancreatic islet cells and role in adaptations to metabolic stress

A Sridhar, PR Flatt, M Draper, AI Tarasov… - Journal of Pharmacy …, 2024 - academic.oup.com
Objectives Dopamine and related receptors are evidenced in pancreatic endocrine tissue,
but the impact on islet β-cell stimulus-secretion as well as (patho) physiological role are …

Three-dimensional characterization of medium spiny neuron heterogeneity in the adult mouse striatum.

J Gayden, S Puig, C Srinivasan, SA Buck… - Biorxiv: the Preprint …, 2023 - europepmc.org
Striatal dopamine (DA) neurotransmission is critical for an array of reward-related behaviors
and goal-directed motor control. In rodents, 95% of striatal neurons are GABAergic medium …

Comparative 4D Label-Free Quantitative Proteomic Analysis of Bombus terrestris Provides Insights into Proteins and Processes Associated with Diapause

Y Liu, L Su, R Wang, X Dai, X Li, Y Chang… - International Journal of …, 2023 - mdpi.com
Diapause, an adaptative strategy for survival under harsh conditions, is a dynamic multi-
stage process. Bombus terrestris, an important agricultural pollinator, is declining in the wild …

Tipepidine activates AMPK and improves adipose tissue fibrosis and glucose intolerance in high‐fat diet‐induced obese mice

A Sawamoto, M Okada, N Matsuoka… - The FASEB …, 2024 - Wiley Online Library
Abstract Tipepidine (3‐[di‐2‐thienylmethylene]‐1‐methylpiperidine)(TP) is a non‐narcotic
antitussive used in Japan. Recently, the potential application of TP in the treatment of …