Sustainable production of natural phenolics for functional food applications

R Mark, X Lyu, JJL Lee, R Parra-Saldívar… - Journal of Functional …, 2019 - Elsevier
Phenolics are a class of plant-derived natural secondary metabolites with good anticancer,
anti-inflammatory, antimicrobial and antioxidant activities. In addition to being natural health …

Biotechnological production of aromatic compounds of the extended shikimate pathway from renewable biomass

JH Lee, VF Wendisch - Journal of biotechnology, 2017 - Elsevier
Aromatic chemicals that contain an unsaturated ring with alternating double and single
bonds find numerous applications in a wide range of industries, eg paper and dye …

Metabolic engineering and synthetic biology approaches driving isoprenoid production in Escherichia coli

C Wang, B Zada, G Wei, SW Kim - Bioresource Technology, 2017 - Elsevier
Isoprenoids comprise the largest family of natural organic compounds with many useful
applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments …

Cellular factories for coenzyme Q10 production

SQE Lee, TS Tan, M Kawamukai, ES Chen - Microbial cell factories, 2017 - Springer
Abstract Coenzyme Q 10 (CoQ 10), a benzoquinone present in most organisms, plays an
important role in the electron-transport chain, and its deficiency is associated with various …

CoQ10 a super-vitamin: review on application and biosynthesis

S Shukla, KK Dubey - 3 Biotech, 2018 - Springer
Coenzyme Q10 (CoQ) or ubiquinone is found in the biological system which is synthesized
by the conjugation of benzoquinone ring with isoprenoid chain of variable length. Coenzyme …

Combinatorial metabolic engineering of Bacillus subtilis for menaquinone‐7 biosynthesis

X Sun, X Bi, G Li, S Cui, X Xu, Y Liu, J Li… - Biotechnology and …, 2024 - Wiley Online Library
Abstract Menaquinone‐7 (MK‐7), a form of vitamin K2, supports bone health and prevents
arterial calcification. Microbial fermentation for MK‐7 production has attracted widespread …

Mechanistic details of early steps in coenzyme Q biosynthesis pathway in yeast

LA Payet, M Leroux, JC Willison, A Kihara, L Pelosi… - Cell chemical …, 2016 - cell.com
Coenzyme Q (Q) is a redox lipid that is central for the energetic metabolism of eukaryotes.
The biosynthesis of Q from the aromatic precursor 4-hydroxybenzoic acid (4-HB) is …

Recent advances in the metabolic pathways and microbial production of coenzyme Q

F Pierrel, A Burgardt, JH Lee, L Pelosi… - World Journal of …, 2022 - Springer
Coenzyme Q (CoQ) serves as an electron carrier in aerobic respiration and has become an
interesting target for biotechnological production due to its antioxidative effect and benefits …

Metabolic Engineering of the MEP Pathway in Bacillus subtilis for Increased Biosynthesis of Menaquinone-7

Y Ma, DD McClure, MV Somerville… - ACS Synthetic …, 2019 - ACS Publications
Vitamin K is essential for blood coagulation and plays important roles in bone and
cardiovascular health. Menaquinone-7 (MK-7) is one form of vitamin K that is especially …

[HTML][HTML] Metabolomics methods for the synthetic biology of secondary metabolism

QT Nguyen, ME Merlo, MH Medema, A Jankevics… - FEBS letters, 2012 - Elsevier
Many microbial secondary metabolites are of high biotechnological value for medicine,
agriculture, and the food industry. Bacterial genome mining has revealed numerous novel …