Saponins: research progress and their potential role in the post-COVID-19 pandemic era

D Mieres-Castro, F Mora-Poblete - Pharmaceutics, 2023 - mdpi.com
In the post-COVID-19 pandemic era, the new global situation and the limited therapeutic
management of the disease make it necessary to take urgent measures in more effective …

Inhibition mechanism of alpha-amylase, a diabetes target, by a steroidal pregnane and pregnane glycosides derived from Gongronema latifolium Benth

OM Ogunyemi, GA Gyebi, A Saheed, J Paul… - Frontiers in molecular …, 2022 - frontiersin.org
Alpha-amylase is widely exploited as a drug target for preventing postprandial
hyperglycemia in diabetes and other metabolic diseases. Inhibition of this enzyme by plant …

GC-MS chemical profiling, antioxidant, anti-diabetic, and anti-inflammatory activities of ethyl acetate fraction of Spilanthes filicaulis (Schumach. and Thonn.) CD …

OA Ojo, AD Ogunlakin, GA Gyebi… - Frontiers in …, 2023 - frontiersin.org
Introduction: This study aimed to investigate the chemical profile of GC-MS, antioxidant, anti-
diabetic, and anti-inflammatory activities of the ethyl acetate fraction of Spilanthes filicaulis …

Elemental evaluation, nutritional analysis, GC-MS analysis and ameliorative effects of Artocarpus communis JRForst. & G.Forst. seeds' phytoconstituents on metabolic syndrome …

AD Ogunlakin, OA Ojo, GA Gyebi… - Journal of …, 2023 - Taylor & Francis
The nutritional as well as beneficial effects of the Artocarpus communis seed on metabolic
syndrome complications have not been studied. In this research, the aim was to investigate …

New Strategies for Responding to SARS-CoV-2: The Present and Future of Dual-Target Drugs

W Zhang, L Xiao, D Li, Y Hu, W Yu - Journal of Medicinal …, 2024 - ACS Publications
The 2019 coronavirus disease (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in millions of deaths, posing a serious …

A Computational Study of Carbazole Alkaloids from Murraya koenigii as Potential SARS-CoV-2 Main Protease Inhibitors

PM Wadanambi, N Jayathilaka… - Applied Biochemistry and …, 2023 - Springer
Despite COVID-19 vaccination, immune escape of new SARS-CoV-2 variants has created
an urgent priority to identify additional antiviral drugs. Targeting main protease (Mpro) …

Therapeutic study of cinnamic acid derivative for oxidative stress ablation: The computational and experimental answers

OA Ojo, AD Ogunlakin, RF Maimako, GA Gyebi… - Molecules, 2023 - mdpi.com
This study aimed to examine the therapeutic activity of the cinnamic acid derivative KAD-7
(N′-(2, 4-dichlorobenzylidene)-3-(4-methoxyphenyl) acrylohydrazide) on Fe2+-induced …

In silico designing of multiepitope-based-peptide (MBP) vaccine against MAPK protein express for Alzheimer's disease in Zebrafish

Y Arfat, I Zafar, SA Sehgal, M Ayaz, M Sajid, JM Khan… - Heliyon, 2023 - cell.com
Understanding the role of the mitogen-activated protein kinases (MAPKs) signalling pathway
is essential in advancing treatments for neurodegenerative disorders like Alzheimer's. In this …

Profiling the antidiabetic potential of GC–MS compounds identified from the methanolic extract of Spilanthes filicaulis: experimental and computational insight

OA Ojo, AD Ogunlakin, GA Gyebi… - Journal of …, 2023 - Taylor & Francis
This study examines the nutritional composition, phytochemical profiling, and antioxidant,
antidiabetic, and anti-inflammatory potential of a methanolic extract of Spilanthes filicaulis …

Effect of Triclisia subcordata Oliv.(Menispermaceae) leaves on hormonal imbalance and genes expression in the ovaries of letrozole-induced polycystic rats via in vivo …

AD Ogunlakin, OA Ojo, GA Gyebi, GO Adebodun… - Journal of Molecular …, 2024 - Elsevier
The hormonal imbalance, insulin sensitivity, and ovarian function are among the biological
processes linked to polycystic ovarian syndrome (PCOS). Hence, in PCOS ovaries, the …