Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

Since the elucidation of the molecular structure of nucleic acids and understanding of their
role in encoding and translating genetic information into biological function, 1 the knowledge …

Background: Ischemic heart disease remains a leading cause of death worldwide. In this
study, we test the hypothesis that microRNA-210 protects the heart from myocardial …

In the 10 years that have passed since the Nobel prize-winning discovery of RNA
interference (RNAi), billions of dollars have been invested in the therapeutic application of …

RNA interference is a naturally occurring endogenous regulatory process where short
double-stranded RNA causes sequence-specific posttranscriptional gene silencing. Small …

Liposomes have been used extensively as micro-and nanocarriers for hydrophobic or
hydrophilic molecules. However, conventional liposomes are biodegradable and quickly …

RNA interference (RNAi) quietly crept into biological research in the 1990s when
unexpected gene-silencing phenomena in plants and flatworms first perplexed scientists …

MicroRNAs (miRNA) aberrantly expressed in tumors may offer novel therapeutic
approaches to treatment. miR-145 is downregulated in various cancers including colon …

Extracellular vesicles (ECVs) are secreted cell-derived membrane particles involved in
intercellular signaling and cell-cell communication. By transporting various bio …

Polymer carriers like PEI which proved their efficiency in DNA delivery were found to be far
less effective for the applications with siRNA. In the current study, we generated a number of …