Abstract The Enhanced Permeability and Retention (EPR) effect has been recognized as the
central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept …

Based on their tunable physicochemical properties and the possibility of producing cell-
specific platforms through surface modification with functional biomolecules, nanoparticles …

Arginine-rich cell-penetrating peptides do not enter cells by directly passing through a lipid
membrane; they instead passively enter vesicles and live cells by inducing membrane …

Gliomas are the most common tumor of the central nervous system. However, the presence
of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of …

Although nanomedicine have greatly developed and human life span has been extended,
we have witnessed the soared incidence of central nervous system (CNS) diseases …

Due to the complex physiological structure, microenvironment and multiple physiological
barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site …

Cell-penetrating peptides (CPPs) are naturally able to cross the lipid bilayer membrane that
protects cells. These peptides share common structural and physicochemical properties and …

The promise of nucleic acid based oligonucleotides as effective genetic therapies has been
held back by their low bioavailability and poor cellular uptake to target tissues upon systemic …

The prevalence of antimicrobial resistance (AMR) has been rising quickly in recent years.
AMR has emerged as a significant obstacle to the treatment of infectious diseases, and …

Glioblastoma is the most common and aggressive brain tumor. Current treatments do not
allow to cure the patients. This is partly due to the blood–brain barrier (BBB), which limits the …