Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …

Chagas disease is one of the most important public health problems in Latin America due to
its high mortality and morbidity levels. There is no effective treatment for this disease since …

This paper describes the development of poly (D, L-lactide-co-glycolide)(PLGA)
nanoparticles (NPs) and nanosuspensions with the polyene antibiotic amphotericin B …

Antifungal drugs such as amphotericin B (AmB) interact with lipids and phospholipids
located on fungal cell membranes to disrupt them and create pores, leading to cell apoptosis …

Amphotericin B (AmB) loaded polymer lipid hybrid nanoparticles (AmB-PLNs) comprised of
lecithin (anionic lipid) and gelatin (Type A, cationic below its isoelectric point 7.0–9.0) were …

Invasive fungal infections can be devastating, particularly in immunocompromised patients,
and difficult to treat with systemic drugs. Furthermore, systemic administration of those …

This study describes the properties of an amphotericin B-containing mucoadhesive
nanostructured lipid carrier (NLC), with the intent to maximize uptake within the …

Amphotericin B (AmB) is a broad-spectrum antifungal drug used in the treatment of fungal
invasive infections. However, its clinical use has been limited due to its side effects and …

Parenteral amphotericin B has been considered as first-line therapy in the treatment of
systemic fungal and parasitic infections, however its use has been associated with a number …

Lipid nanoparticles (LNPs) as nano-scale drug carriers that can entrap poorly water-soluble
drugs such as amphotericin B (AmB) in aqueous solution with high drug entrapment …