Peripheral nerve sheath tumors are common neoplasms, with classic identifiable features,
but on occasion, they are diagnostically challenging. Although well-defined subtypes of …

Significant progress has been made in understanding the molecular genetic alterations
involved in sarcomagenesis. Cytogenetic and molecular studies have identified nonrandom …

Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of
NF1, CDKN2A, and polycomb repressive complex 2 component genes (Embryonic …

Transducer-like enhancer of split 1 (TLE1) is overexpressed in synovial sarcomas. We
investigated TLE1 expression by immunohistochemical analysis in a well-characterized …

Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal
event generates SS18-SSX fusion transcripts. In vitro and in vivo studies have shown that …

Immunohistochemistry is an integral component in the proper analysis of soft tissue tumours,
and a simple panel of six markers is useful in practical triage: CD 34, desmin, epithelial …

Synovial sarcoma and malignant peripheral nerve sheath tumor pose a significant
diagnostic challenge given similar histomorphology. The distinction is further complicated by …

Clear cell sarcoma–like tumor of the gastrointestinal tract (CCSLGT) is a rare malignant
neoplasm that occurs in the wall of the small bowel, stomach, or large bowel, predominantly …

Immunohistochemistry plays a key role in the diagnosis of soft tissue tumors. Until recently,
however, the primary purpose of immunohistochemistry in this context was simply to attempt …

Methods: Conventional sections from 42 synovial sarcomas (30 retrospective & 12
prospectively diagnosed) were subjected to TLE1 IHC staining, including 21 tumours …