Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

The authors define molecular imaging, according to the Society of Nuclear Medicine and
Molecular Imaging, as the visualization, characterization, and measurement of biological …

Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …

The natural history and treatment landscape of primary brain tumours are complicated by the
varied tumour behaviour of primary or secondary gliomas (high-grade transformation of low …

Transformed cells adapt metabolism to support tumor initiation and progression. Specific
metabolic activities can participate directly in the process of transformation or support the …

Once an MRS dataset has been acquired, several important steps must be taken to obtain
the desired metabolite concentration measures. First, the data must be preprocessed to …

Tumorigenesis is dependent on the reprogramming of cellular metabolism as both direct
and indirect consequence of oncogenic mutations. A common feature of cancer cell …

Proton MRS (1H MRS) provides noninvasive, quantitative metabolite profiles of tissue and
has been shown to aid the clinical management of several brain diseases. Although most …

Oxoglutarate-dependent dioxygenases (2OGDDs) are a superfamily of enzymes that play
diverse roles in many biological processes, including regulation of hypoxia-inducible factor …

The impact of targeted therapies in glioma has been modest. All the therapies that have
demonstrated a significant survival benefit for gliomas in Phase III trials, including radiation …