Calcium carries messages to virtually all important functions of cells. Although it was already
active in unicellular organisms, its role became universally important after the transition to …

“Ca2+ buffers,” a class of cytosolic Ca2+-binding proteins, act as modulators of short-lived
intracellular Ca2+ signals; they affect both the temporal and spatial aspects of these …

Calpain is an intracellular Ca2+-dependent cysteine protease (EC 3.4. 22.17; Clan CA,
family C02). Recent expansion of sequence data across the species definitively shows that …

Aims: To survey the expression of members of the S100 family of calcium‐binding proteins
in normal human tissues and common cancers using tissue microarrays. S100A6, S100A8 …

Calpains are members of a large family of Ca2+-dependent proteolytic enzymes. Some are
tissue-specific; others are ubiquitous. Poised to digest numerous intracellular proteins, their …

Background Mesenchymal stem (MS) cells are excellent candidates for cell-based
therapeutic strategies to regenerate injured tissue. Although human MS cells can be isolated …

We have proposed that reactive oxygen species (ROS) play essential roles in cell
differentiation. Enzymes belonging to the NADPH oxidase (NOX) family produce superoxide …

Phosphatidylcholine (1, 2-diacyl-sn-glycero-3-phosphocholine, PC), is an important
constituent of biological membranes. It is also the major component of serum lipoproteins …

▪ Abstract All microorganisms must adapt to the pH of their environment. One aspect of this
adaptation, particularly important for organisms that grow over a wide pH range, is the ability …

Alix is a cytosolic protein in mammalian cells that was originally identified on the basis of its
association with pro-apoptotic signaling. More recent evidence has established that Alix has …