[HTML][HTML] Neurocircuitry of addiction
GF Koob, ND Volkow - Neuropsychopharmacology, 2010 - nature.com
Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …
Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development
GF Koob - Pharmacological Reviews, 2021 - ASPET
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
Theory of addiction
The word 'addiction'these days is used to refer to a chronic condition where there is an
unhealthily powerful motivation to engage in a particular behaviour. This can be driven by …
unhealthily powerful motivation to engage in a particular behaviour. This can be driven by …
Addiction and the brain antireward system
GF Koob, M Le Moal - Annu. Rev. Psychol., 2008 - annualreviews.org
A neurobiological model of the brain emotional systems has been proposed to explain the
persistent changes in motivation that are associated with vulnerability to relapse in …
persistent changes in motivation that are associated with vulnerability to relapse in …
[HTML][HTML] A role for brain stress systems in addiction
GF Koob - Neuron, 2008 - cell.com
Drug addiction is a chronically relapsing disorder characterized by compulsion to seek and
take drugs and has been linked to dysregulation of brain regions that mediate reward and …
take drugs and has been linked to dysregulation of brain regions that mediate reward and …
Neurobiological mechanisms for opponent motivational processes in addiction
GF Koob, M Le Moal - … of the Royal Society B: Biological …, 2008 - royalsocietypublishing.org
The conceptualization of drug addiction as a compulsive disorder with excessive drug intake
and loss of control over intake requires motivational mechanisms. Opponent process as a …
and loss of control over intake requires motivational mechanisms. Opponent process as a …
Addiction as vulnerabilities in the decision process
AD Redish, S Jensen, A Johnson - Behavioral and brain sciences, 2008 - cambridge.org
In our target article, we proposed that addiction could be envisioned as misperformance of a
decision-making machinery described by two systems (deliberative and habit systems) …
decision-making machinery described by two systems (deliberative and habit systems) …
Neurobiology of addiction
GF Koob - Focus, 2011 - Am Psychiatric Assoc
Drug addiction, also known as substance dependence, is a chronically relapsing disorder
characterized by (1) compulsion to seek and take the drug,(2) loss of control in limiting …
characterized by (1) compulsion to seek and take the drug,(2) loss of control in limiting …
Co-occurring mental and substance use disorders: the neurobiological effects of chronic stress
The high rate of co-occurrence of substance use disorders and other psychiatric disorders is
well established. The population of people with co-occurring disorders is heterogeneous …
well established. The population of people with co-occurring disorders is heterogeneous …
Cognitive adaptation under stress: a case for the mineralocorticoid receptor
Corticosteroid hormones, released during stressful encounters, have profound and far-
reaching effects on cognition. They are often thought to accomplish these effects primarily …
reaching effects on cognition. They are often thought to accomplish these effects primarily …