Many important interactions between bacterial pathogens and their hosts are highly specific
binding events that involve host or pathogen carbohydrate structures (glycans). Glycan …

This review comprises aspects of the epidemiology, microbiology, pathophysiology, clinical
manifestations, diagnosis, management, prognosis, and prevention of bacterial meningitis …

Meningococcal disease occurs worldwide with incidence rates varying from 1 to 1000 cases
per 100,000. The causative organism, Neisseria meningitidis, is an obligate commensal of …

During periods of endemic disease, about 10% of the general population harbour Neisseria
meningitidis in the nasopharynx. Since N. meningitidis is a strict human pathogen and most …

Sepsis and meningitis caused by serogroup B meningococcus are devastating diseases of
infants and young adults, which cannot yet be prevented by vaccination. By genome mining …

ABSTRACT A novel antigen that induces cross-reactive bactericidal antibodies against a
number of Neisseria meningitidis strains is described. This antigen, a∼ 28-kDa lipoprotein …

Background: The specific targeting of nanomedicines to mannose receptors, highly
expressed in cells of the immune system, performs a useful strategy for improving the …

Neisseria meningitidis, an obligate commensal of humans, normally colonizes the mucosa
of the upper respiratory tract without affecting the host, a phenomenon known as carriage. In …

Cryptococcus neoformans is a yeast responsible for disseminated meningoencephalitis in
patients with cellular immune defects. The major virulence factor is the polysaccharide …

Neisseria meningitidis is the leading cause of bacterial meningitis in the United States and
worldwide. A serogroup A/C/W-135/Y polysaccharide meningococcal vaccine has been …