RAD51 Gene Family Structure and Function

B Bonilla, SR Hengel, MKK Grundy… - Annual review of …, 2020 - annualreviews.org
Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …

Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair

LS Symington - Microbiology and molecular biology reviews, 2002 - Am Soc Microbiol
The process of homologous recombination is a major DNA repair pathway that operates on
DNA double-strand breaks, and possibly other kinds of DNA lesions, to promote error-free …

The mouse Spo11 gene is required for meiotic chromosome synapsis

PJ Romanienko, RD Camerini-Otero - Molecular cell, 2000 - cell.com
The Spo11 protein initiates meiotic recombination by generating DNA double-strand breaks
(DSBs) and is required for meiotic synapsis in S. cerevisiae. Surprisingly, Spo11 homologs …

DNA strand exchange and RecA homologs in meiosis

MS Brown, DK Bishop - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
Homology search and DNA strand–exchange reactions are central to homologous
recombination in meiosis. During meiosis, these processes are regulated such that the …

Recombination proteins in yeast

BO Krogh, LS Symington - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract The process of homologous recombination promotes error-free repair of double-
strand breaks and is essential for meiosis. Central to the process of homologous …

Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis

V Cloud, YL Chan, J Grubb, B Budke, DK Bishop - Science, 2012 - science.org
Meiotic recombination in budding yeast requires two RecA-related proteins, Rad51 and
Dmc1, both of which form filaments on DNA capable of directing homology search and …

[HTML][HTML] The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis

K Yoshida, G Kondoh, Y Matsuda, T Habu… - Molecular cell, 1998 - cell.com
The mouse Dmc1 gene is an E. coli RecA homolog that is specifically expressed in meiosis.
The DMC1 protein was detected in leptotene-to-zygotene spermatocytes, when homolog …

Clarifying the mechanics of DNA strand exchange in meiotic recombination

MJ Neale, S Keeney - Nature, 2006 - nature.com
During meiosis, accurate separation of maternal and paternal chromosomes requires that
they first be connected to one another through homologous recombination. Meiotic …

Random Chromosome Segregation without Meiotic Arrest in Both Male and Female Meiocytes of a dmc1 Mutant of Arabidopsis

F Couteau, F Belzile, C Horlow, O Grandjean… - The Plant …, 1999 - academic.oup.com
In yeast, the DMC1 gene is required for interhomolog recombination, which is an essential
step for bivalent formation and the correct partition of chromosomes during meiosis I. By …

Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae

T Strahl, J Thorner - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2007 - Elsevier
It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …