Therapeutic potential of palm oil vitamin E-derived tocotrienols in inflammation and chronic diseases: Evidence from preclinical and clinical studies

Z Zainal, H Khaza'ai, AK Radhakrishnan… - Food Research …, 2022 - Elsevier
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …

Current approach to the pathogenesis of diabetic cataracts

M Mrugacz, M Pony-Uram, A Bryl, K Zorena - International Journal of …, 2023 - mdpi.com
Cataracts remain the first or second leading cause of blindness in all world regions. In the
diabetic population, cataracts not only have a 3–5 times higher incidence than in the healthy …

Revisiting the therapeutic potential of tocotrienol

R Ranasinghe, M Mathai, A Zulli - Biofactors, 2022 - Wiley Online Library
The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a
dietary supplement. It is largely considered to be safe when consumed at low doses for …

Reported evidence of vitamin E protection against cataract and glaucoma

M Tanito - Free Radical Biology and Medicine, 2021 - Elsevier
Cataract and glaucoma are the major causes of severe visual loss and blindness in older
adults. This review article describes the currently available basic and clinical evidence …

Potential role of tocotrienols on non-communicable diseases: a review of current evidence

SK Wong, Y Kamisah, N Mohamed, N Muhammad… - Nutrients, 2020 - mdpi.com
Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties.
This review aimed to summarize the health benefits of T3, particularly in prevention or …

[HTML][HTML] Antioxidant and anti-apoptotic effects of tocotrienol-rich fraction against streptozotocin-induced diabetic retinopathy in rats

MZ Sadikan, NAA Nasir, I Iezhitsa, R Agarwal - Biomedicine & …, 2022 - Elsevier
Oxidative stress, a key player in diabetic retinopathy (DR), is associated with retinal cell
apoptosis. This study investigated the effect of tocotrienol-rich fraction (TRF), a potent …

The role of tocotrienol in protecting against metabolic diseases

KL Pang, KY Chin - Molecules, 2019 - mdpi.com
Obesity is a major risk factor for diabetes, and these two metabolic conditions cause
significant healthcare burden worldwide. Chronic inflammation and increased oxidative …

Coenzyme Q10: A Key Antioxidant in the Management of Diabetes‐Induced Cardiovascular Complications—An Overview of Mechanisms and Clinical Evidence

F Samimi, N Namiranian, A Sharifi-Rigi… - International Journal …, 2024 - Wiley Online Library
Background. Diabetes mellitus (DM) presents a significant global health challenge with
considerable cardiovascular implications. Coenzyme Q10 (CoQ10) has gained recognition …

Puerarin prevents cataract development and progression in diabetic rats through Nrf2/HO‑1 signaling

D Zhang, M Li - Molecular Medicine Reports, 2019 - spandidos-publications.com
Puerarin is the major bioactive ingredient isolated from the dry root of Pueraria lobata, a
plant used in traditional Chinese medicine. Puerarin has been used to treat diabetes and …

Anti-inflammatory and antioxidant properties of rice bran oil extract in copper sulfate-induced inflammation in zebrafish (Danio rerio)

N Liu, P Zhang, M Xue, M Zhang, Z Xiao, C Xu… - Fish & Shellfish …, 2023 - Elsevier
Tocotrienols have strong antioxidant properties; however, tocotrienol has not been
investigated in detail in aquatic products. In this study, the anti-inflammatory and antioxidant …