Secondary immunodeficiency in hematological malignancies: focus on multiple myeloma and chronic lymphocytic leukemia

A Allegra, A Tonacci, C Musolino, G Pioggia… - Frontiers in …, 2021 - frontiersin.org
Secondary immunodeficiency is reported in most patients with hematological malignancies
such as chronic lymphocytic leukemia and multiple myeloma. The aim of our review was to …

ALPINE: zanubrutinib versus ibrutinib in relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma

P Hillmen, JR Brown, BF Eichhorst, N Lamanna… - Future …, 2020 - Taylor & Francis
Treatment standards for chronic lymphocytic leukemia (CLL) have been transformed with the
advent of effective inhibitors of B-cell receptor signaling such as ibrutinib–a first-in-class …

Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity

KS Reiners, D Topolar, A Henke… - Blood, The Journal …, 2013 - ashpublications.org
Natural killer (NK) cells are a major component of the anti-tumor immune response. NK cell
dysfunctions have been reported in various hematologic malignancies, including chronic …

Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL

G Ferrer, B Jung, PY Chiu, R Aslam, F Palacios… - Leukemia, 2021 - nature.com
Cancer pathogenesis involves the interplay of tumor-and microenvironment-derived stimuli.
Here we focused on the influence of an immunomodulatory cell type, myeloid-derived …

Transforming CLL management with immunotherapy: investigating the potential of CAR T-cells and bispecific antibodies

A Borogovac, T Siddiqi - Seminars in hematology, 2024 - Elsevier
Immunotherapies, such as chimeric antigen receptor (CAR) T-cell therapy and bispecific
antibodies or T-cell engagers, have revolutionized the treatment landscape for various B-cell …

Persistent severe acute respiratory syndrome coronavirus 2 infection in immunocompromised host displaying treatment induced viral evolution

I Monrad, SR Sahlertz, SSF Nielsen… - Open forum …, 2021 - academic.oup.com
We report a coronavirus disease 2019 case with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised …

Dysregulated expression of Tim-3 and NKp30 receptors on NK cells of patients with chronic lymphocytic leukemia

L Hadadi, M Hafezi, AA Amirzargar… - Oncology research and …, 2019 - karger.com
Background: In this study, the expression pattern of NKp30 and T cell immunoglobulin and
mucin domain-containing molecule-3 (Tim-3), as candidates for activating and inhibitory …

Optimal management of skin cancer in immunosuppressed patients

L Brin, AS Zubair, JD Brewer - American journal of clinical dermatology, 2014 - Springer
Skin cancer is the most common malignancy in humans with basal cell carcinoma
representing the majority of cases in the general population. The prevalence of skin cancer …

Chronic lymphocytic leukemia-induced humoral immunosuppression: a systematic review

E Grywalska, M Zaborek, J Łyczba, R Hrynkiewicz… - Cells, 2020 - mdpi.com
Secondary immunodeficiency is observed in all patients with chronic lymphocytic leukemia
(CLL) in varying degrees. The aim of the study was to review the available literature data on …

Biology and treatment advances in cutaneous squamous cell carcinoma

AA Thai, AM Lim, BJ Solomon, D Rischin - Cancers, 2021 - mdpi.com
Simple Summary Skin cancers are the most diagnosed type of cancer worldwide.
Cutaneous squamous cell carcinoma—a type of skin cancer—usually affects older people …