Cellular membranes function as permeability barriers that separate cells from the external
environment or partition cells into distinct compartments. These membranes are lipid …

Glycerophospholipids, sphingolipids and cholesterol assemble into lipid bilayers that form
the scaffold of cellular membranes, in which proteins are embedded. Membrane …

TMEM16F, a member of the conserved TMEM16 family, plays a central role in the initiation
of blood coagulation and the fusion of trophoblasts. The protein mediates passive ion and …

Abstract Transmembrane protein 16 F (TMEM16F) is a Ca2+-activated homodimer which
functions as an ion channel and a phospholipid scramblase. Despite the availability of …

Abstract Major Facilitator Superfamily Domain containing 2 A (MFSD2A) is a transporter that
is highly enriched at the blood-brain and blood-retinal barriers, where it mediates Na+ …

The “eat me” signal, phosphatidylserine is exposed on the surface of dying cells by
phospholipid scrambling. Previously, we showed that the Xkr family protein Xkr4 is activated …

Activation of Ca 2+-dependent TMEM16 scramblases induces the externalization of
phosphatidylserine, a key molecule in multiple signaling processes. Current models suggest …

Many biological membranes host different lipid species in their two leaflets. Since their
spontaneous curvatures are typically not the same, this compositional asymmetry generally …

Phospholipid scramblases mediate the rapid movement of lipids between membrane
leaflets, a key step in establishing and maintaining membrane homeostasis of the …

This study focuses on investigating the effects of an oncogenic mutation (G12V) on the
stability and interactions within the KRAS‐RGL1 protein complex. The KRAS‐RGL1 complex …