Nearly all FDA approved drugs and bioactive small molecules exert their effects by binding
to and modulating proteins. Consequently, understanding how small molecules interact with …

Photoaffinity labeling (PAL) is one of the few biochemical techniques that can give direct
evidence of biomolecular interactions in cells. Several photoactivatable functional groups …

The most used approaches in structure-based drug design possess peculiar characteristics
with advantages and limitations, and thus the management of complementary data from …

ABSTRACT A novel coronavirus recently identified in Wuhan, China (2019-nCoV) has
resulted in an increasing number of patients globally, and has become a highly lethal …

Bioorthogonal reactions are rapid, specific and high yield reactions that can be performed in
in vivo microenvironments or simulated microenvironments. At present, the main …

Facing the sudden outbreak of coronavirus disease 2019 (COVID‐19), it is extremely urgent
to develop effective antiviral drugs against severe acute respiratory syndrome coronavirus 2 …

To develop new and potent therapies against human immunodeficiency virus infections, a
series of 3-acetyl-2H-1-benzopyran-2-one derivatives (2a-n) were synthesized and …

Leishmaniasis is a complex group of vector-borne zoonosis caused by parasites of the
Leishmania genus. The prediction of annual cases of visceral leishmaniasis and cutaneous …

This year, ACS Medicinal Chemistry Letters celebrates its 10th anniversary. To recognize
this occasion, we are publishing a Special Issue entitled “Medicinal Chemistry: From Targets …