Insulin resistance and cancer risk: an overview of the pathogenetic mechanisms

B Arcidiacono, S Iiritano, A Nocera… - Journal of Diabetes …, 2012 - Wiley Online Library
Insulin resistance is common in individuals with obesity or type 2 diabetes (T2D), in which
circulating insulin levels are frequently increased. Recent epidemiological and clinical …

Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases

CC Chuang, MK McIntosh - Annual review of nutrition, 2011 - annualreviews.org
Obesity and metabolic disease–related health problems (eg, type 2 diabetes,
atherosclerosis, and hypertension) are the most prevalent nutrition-related issues in the …

Metformin induces apoptosis and cell cycle arrest mediated by oxidative stress, AMPK and FOXO3a in MCF-7 breast cancer cells

EAIF Queiroz, S Puukila, R Eichler, SC Sampaio… - PloS one, 2014 - journals.plos.org
Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct
antitumoral effects, or can indirectly decrease tumor proliferation by improving insulin …

[HTML][HTML] The spatial association between environmental pollution and long-term cancer mortality in Italy

RC Gatti, A Di Paola, A Monaco… - Science of the Total …, 2023 - Elsevier
Tumours are nowadays the second world‑leading cause of death after cardiovascular
diseases. During the last decades of cancer research, lifestyle and random/genetic factors …

The role of hepatocyte growth factor (HGF) in insulin resistance and diabetes

AG Oliveira, TG Araújo, BM Carvalho… - Frontiers in …, 2018 - frontiersin.org
In obesity, insulin resistance (IR) and diabetes, there are proteins and hormones that may
lead to the discovery of promising biomarkers and treatments for these metabolic disorders …

The role of chronic inflammation in obesity‐associated cancers

ME Ramos-Nino - International Scholarly Research Notices, 2013 - Wiley Online Library
There is a strong relationship between metabolism and immunity, which can become
deleterious under conditions of metabolic stress. Obesity, considered a chronic inflammatory …

The diversity of nutritional status in cancer: new insights

M Ramos Chaves, C Boléo-Tomé… - The …, 2010 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Explain
how malnutrition (deficit or excess) is used as a decisive factor in treatment of cancer …

Epidemiology of renal cell cancer

E Cho, HO Adami, P Lindblad - Hematology/Oncology …, 2011 - hemonc.theclinics.com
More than 90% of kidney cancers arise in the renal parenchyma, and the remainder in the
renal pelvis. 1 Most cancers in the parenchyma are renal cell carcinomas (RCC), a …

Adipocytes: impact on tumor growth and potential sites for therapeutic intervention

S Hefetz-Sela, PE Scherer - Pharmacology & therapeutics, 2013 - Elsevier
The prevalence of obesity has increased dramatically in recent decades, reaching epidemic
proportions. It is becoming clear that obesity is associated not only with type 2 diabetes …

Artificial light-at-night–a novel lifestyle risk factor for metabolic disorder and cancer morbidity

AE Zubidat, A Haim - Journal of basic and clinical physiology and …, 2017 - degruyter.com
Both obesity and breast cancer are already recognized worldwide as the most common
syndromes in our modern society. Currently, there is accumulating evidence from …