Abstract G-quadruplexes (G4s), higher-order DNA and RNA secondary structures featuring
guanine-rich nucleic acid sequences with various conformations, are widely distributed in …

G-rich nucleic acids can form non-canonical G-quadruplex structures (G4s) in which four
guanines fold in a planar arrangement through Hoogsteen hydrogen bonds. Although many …

Guanine-rich DNA sequences of a particular form have the ability to fold into four-stranded
structures called G-quadruplexes. In this paper, we present a working rule to predict which …

The expansion of repeated sequences is the cause of over 30 inherited genetic diseases,
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …

Substantial progress has been realized in the past several years in our understanding of the
molecular mechanisms responsible for the expansions and deletions (genetic instabilities) …

Epilepsy afflicts 1% of humans and 5% of dogs. We report a canine epilepsy mutation and
evidence for the existence of repeat-expansion disease outside humans. A canid-specific …

Large numbers of guanine-rich sequences with potential to form G-quadruplexes have been
identified in genomes of various organisms. Such sequences are constrained at both ends …

Introduction 3. Biological significance of tetraplex DNA 3.1. Evidence for the existence of
tetraplex DNA in vivo 3.2. Proposed biological roles of tetraplex DNA. 3.2. 1. Functions in the …

Alterations in the length (instability) of gene-specific microsatellites and minisatellites are
associated with at least 35 human diseases. This review will discuss the various cis …

Summary Unverricht–Lundborg disease (EPM1) is an autosomal recessively inherited
neurodegenerative disorder and the most common single cause of progressive myoclonus …