Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic β-cells (or β-
cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for …

Type 2 diabetes (T2D) is a growing cause of poor health, psychosocial burden, and
economic costs worldwide. The pancreatic β-cell is a cornerstone of metabolic physiology …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Rare diseases are life-threatening or chronically debilitating low-prevalent disorders caused
by pathogenic mutations or particular environmental insults. Due to their high complexity …

Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes
mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and progressive …

Calcium ions (Ca2+) operate as important messengers in the cell, indispensable for
signaling the underlying numerous cellular processes in all of the cell types in the human …

Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the
WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive …

Aims/hypothesis Wolfram syndrome is a rare autosomal recessive disorder caused by
pathogenic variants in the WFS1 gene. It is characterised by insulin-dependent diabetes …

Madhurakshak Activ (MA), a commercial polyherbal antidiabetic preparation is known to
manage diabetes mellitus (DM) by reducing blood glucose levels. However, lacks …

Wolfram syndrome (WS) is a rare neurodegenerative disease resulting in deafness, optic
atrophy, diabetes, and neurological disorders. Currently, no treatment is available for …