The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …

The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they
encounter during tumour development. Aberrant reactivation of epithelial–mesenchymal …

Interactions of cancer cells with the primary tumor microenvironment are important
determinants of cancer progression toward metastasis but it is unknown whether additional …

Cancer cells that leave the primary tumor can seed metastases in distant organs, and it is
thought that this is a unidirectional process. Here we show that circulating tumor cells …

Systemic cancer progression is accounted for in two basic models. The prevailing archetype
places the engine of cancer progression within the primary tumour before metastatic …

MicroRNAs (miRNAs) are increasingly implicated in the regulation of metastasis. Despite
their potential as targets for anti-metastatic therapy, miRNAs have only been silenced in …

Portal vein tumor thrombosis (PVTT) is a significant risk factor for metastasis in
hepatocellular carcinoma (HCC) patients and is therefore associated with poor prognosis …

Cancer progress is accompanied by platelet activation and thrombotic complications.
Platelets are a dangerous alliance of cancer cells, and are a close engager in multiple …

Stem cell‐based therapies exhibit profound therapeutic potential for treating various human
diseases, including cancer. Among the cell types that can be used for this purpose …

Epithelial–mesenchymal transition (EMT) is a key step during embryogenesis. Accumulating
evidence suggests a critical role in cancer progression, through which tissue epithelial …