Traumatic brain injury and risk of neurodegenerative disorder
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …
Chronic neuropathologies of single and repetitive TBI: substrates of dementia?
Traumatic brain injury (TBI) has long been recognized to be a risk factor for dementia. This
association has, however, only recently gained widespread attention through the increased …
association has, however, only recently gained widespread attention through the increased …
LATE-NC staging in routine neuropathologic diagnosis: an update
An international consensus report in 2019 recommended a classification system for limbic-
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
predominant age-related TDP-43 encephalopathy neuropathologic changes (LATE-NC) …
Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS
AN Coyne, V Baskerville, BL Zaepfel… - Science translational …, 2021 - science.org
Alterations in the components [nucleoporins (Nups)] and function of the nuclear pore
complex (NPC) have been implicated as contributors to the pathogenesis of genetic forms of …
complex (NPC) have been implicated as contributors to the pathogenesis of genetic forms of …
Inflammation and white matter degeneration persist for years after a single traumatic brain injury
VE Johnson, JE Stewart, FD Begbie, JQ Trojanowski… - Brain, 2013 - academic.oup.com
A single traumatic brain injury is associated with an increased risk of dementia and, in a
proportion of patients surviving a year or more from injury, the development of hallmark …
proportion of patients surviving a year or more from injury, the development of hallmark …
[HTML][HTML] The neuropathology and neurobiology of traumatic brain injury
K Blennow, J Hardy, H Zetterberg - Neuron, 2012 - cell.com
The acute and long-term consequences of traumatic brain injury (TBI) have received
increased attention in recent years. In this Review, we discuss the neuropathology and …
increased attention in recent years. In this Review, we discuss the neuropathology and …
Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood
Mild traumatic brain injury (TBI), which is defined as a head trauma resulting in a brief loss of
consciousness and/or alteration of mental state, is usually benign, but occasionally causes …
consciousness and/or alteration of mental state, is usually benign, but occasionally causes …
Progressive inflammation‐mediated neurodegeneration after traumatic brain or spinal cord injury
Traumatic brain injury (TBI) has been linked to dementia and chronic neurodegeneration.
Described initially in boxers and currently recognized across high contact sports, the …
Described initially in boxers and currently recognized across high contact sports, the …
Lifetime traumatic brain injury and cognitive domain deficits in late life: the PROTECT-TBI cohort study
Traumatic brain injury (TBI) causes cognitive impairment but it remains contested regarding
which cognitive domains are most affected. Further, moderate-severe TBI is known to be …
which cognitive domains are most affected. Further, moderate-severe TBI is known to be …
Repetitive head impacts and chronic traumatic encephalopathy are associated with TDP-43 inclusions and hippocampal sclerosis
R Nicks, NF Clement, VE Alvarez, Y Tripodis… - Acta …, 2023 - Springer
Hippocampal sclerosis (HS) is associated with advanced age as well as transactive
response DNA-binding protein with 43 kDa (TDP-43) deposits. Both hippocampal sclerosis …
response DNA-binding protein with 43 kDa (TDP-43) deposits. Both hippocampal sclerosis …