Biomaterials: foreign bodies or tuners for the immune response?

E Mariani, G Lisignoli, RM Borzì… - International journal of …, 2019 - mdpi.com
The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

Controlling protein adsorption through nanostructured polymeric surfaces

I Firkowska‐Boden, X Zhang… - Advanced healthcare …, 2018 - Wiley Online Library
The initial host response to healthcare materials' surfaces after implantation is the
adsorption of proteins from blood and interstitial fluids. This adsorbed protein layer …

Optimized nanointerface engineering of micro/nanostructured titanium implants to enhance cell–nanotopography interactions and osseointegration

K Li, S Liu, T Hu, I Razanau, X Wu, H Ao… - ACS Biomaterials …, 2020 - ACS Publications
The success of orthopedic implants requires rapid and complete osseointegration which
relies on an implant surface with optimal features. To enhance cellular function in response …

Preparation, properties, and bioapplications of block copolymer nanopatterns

R Fontelo, RL Reis, R Novoa‐Carballal… - Advanced …, 2024 - Wiley Online Library
Block copolymer (BCP) self‐assembly has emerged as a feasible method for large‐scale
fabrication with remarkable precision–features that are not common for most of the …

On the relationship between structure and catalytic effectiveness in solid surface-immobilized enzymes: Advances in methodology and the quest for a single-molecule …

JM Bolivar, B Nidetzky - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2020 - Elsevier
The integration of enzymes with solid materials is important in many biotechnological
applications, including the use of immobilized enzymes for biocatalytic synthesis. The …

Decoding the “Fingerprint” of implant materials: Insights into the foreign body reaction

Y Chen, Z Luo, W Meng, K Liu, Q Chen, Y Cai, Z Ding… - Small, 2024 - Wiley Online Library
Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon,
particularly within the field of biomedical implantation. The presence of FBR poses a heavy …

How nanotopography-induced conformational changes of fibrinogen affect platelet adhesion and activation

I Firkowska-Boden, C Helbing, TJ Dauben, M Pieper… - Langmuir, 2020 - ACS Publications
The conformational state of adsorbed human plasma fibrinogen (HPF) has been recognized
as the determinant factor in platelet adhesion and thrombus formation on blood-contacting …

Protein–polymer interaction characteristics unique to nanoscale interfaces: A perspective on recent insights

DH Cho, J Hahm - The Journal of Physical Chemistry B, 2021 - ACS Publications
Protein interactions at polymer interfaces represent a complex but ubiquitous phenomenon
that demands an entirely different focus of investigation than what has been attempted …

Clopidogrel eluting electrospun polyurethane/polyethylene glycol thromboresistant, hemocompatible nanofibrous scaffolds

AA Shitole, PS Giram, PW Raut… - Journal of …, 2019 - journals.sagepub.com
Biomaterials used as blood-contacting material must be hemocompatible and exhibit lower
thrombotic potential while maintaining hemostasis and angiogenesis. With the aim of …

Predicting the in vivo performance of cardiovascular biomaterials: current approaches in vitro evaluation of blood-biomaterial interactions

A Strohbach, R Busch - International Journal of Molecular Sciences, 2021 - mdpi.com
The therapeutic efficacy of a cardiovascular device after implantation is highly dependent on
the host-initiated complement and coagulation cascade. Both can eventually trigger …