The number of infants infected with HIV is declining with the rise in interventions for the
elimination of paediatric HIV infection, but the number of uninfected infants exposed to HIV …

Co-trimoxazole is an inexpensive, broad-spectrum antimicrobial drug that is widely used in
developing countries. Before antiretroviral therapy (ART) scale-up, co-trimoxazole …

Background Children with complicated severe acute malnutrition (SAM) have a greatly
increased risk of mortality from infections while in hospital and after discharge. In HIV …

Although evidence suggests that T cells are critical for immunity to malaria, reliable T cell
correlates of exposure to and protection from malaria among children living in endemic …

Background Chemoprevention offers a promising strategy for prevention of malaria in
African children. However, the optimal chemoprevention drug and dosing strategy is unclear …

Background The burden of malaria has decreased in parts of Africa following the scaling up
of control interventions. However, similar data are limited from high transmission settings …

Malaria, a parasite vector-borne disease, is one of the most significant health threats in
tropical regions, despite the availability of individual chemoprophylaxis. Malaria …

Malaria is one of the most life-threatening infectious diseases and constitutes a major health
problem, especially in Africa. Although artemisinin combination therapies remain efficacious …

Introduction Cotrimoxazole (CTX) has been used for half a century. It is inexpensive hence
the reason for its almost universal availability and wide clinical spectrum of use. In the last …

Antibiotic consumption is a key driver of antibiotic resistance (AR), particularly in low-and
middle-income countries, where risk factors for AR emergence and spread are rife …