Machine learning and deep learning approaches for enhanced prediction of hERG blockade: a comprehensive QSAR modeling study
Background Cardiotoxicity is a major cause of drug withdrawal. The hERG channel,
regulating ion flow, is pivotal for heart and nervous system function. Its blockade is a concern …
regulating ion flow, is pivotal for heart and nervous system function. Its blockade is a concern …
Biophysical assays to test cellular mechanosensing: moving towards high throughput
M Cubero-Sarabia, AM Kapetanaki, M Vassalli - Biophysical Reviews, 2024 - Springer
Mechanosensitivity is the ability of cells to sense and respond to mechanical stimuli. In order
to do this, cells are endowed with different components that allow them to react to a broad …
to do this, cells are endowed with different components that allow them to react to a broad …
[HTML][HTML] From viruses to humans–Exploring the structure–function relationship of the Kesv protein for the future of biomedicine
Viruses often use ion channel proteins to initialise host infections. Defects in ion channel
proteins are also linked to several metabolic disorders in humans. In that instance …
proteins are also linked to several metabolic disorders in humans. In that instance …
Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons
Peripheral sensory neurons are a primary effector in pain neurotransmission, and have
become a useful cellular model for the study of pain. While rodent tissue has historically …
become a useful cellular model for the study of pain. While rodent tissue has historically …