This review article provides an update of the empirical research on cognitive fragility
conducted in the last four years. The studies retrieved were classified in four different …

Background As the global population ages, the issue of frailty in older people is gaining
international attention. As one of the major subtypes of frailty, cognitive frailty is a …

Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to
Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we …

Introduction This study assessed the hypothesis that circulating human amylin (amyloid‐
forming) cross‐seeds with amyloid beta (Aβ) in early Alzheimer's disease (AD). Methods …

Type‐2 diabetes raises the risk for Alzheimer's disease (AD)‐type dementia and the
conversion from mild cognitive impairment to dementia, yet mechanisms connecting type‐2 …

Islet amyloid polypeptide (amylin) secreted from the pancreas crosses from the blood to the
brain parenchyma and forms cerebral mixed amylin-β amyloid (Aβ) plaques in persons with …

Importance Dementia is an “overdetermined” syndrome. Few individuals are demented by
any single biomarker, while several may independently explain small fractions of dementia …

Background: We have explored dementia's blood-based protein biomarkers in the Texas
Alzheimer's Research and Care Consortium (TARCC) study. Among them are adipokines …

Amylin is a systemic neuroendocrine hormone co-expressed and co-secreted with insulin by
pancreatic β-cells. In persons with thype-2 diabetes, amylin forms pancreatic amyloid …

Brain sciences and the R words | Brain Communications | Oxford Academic Skip to Main
Content Advertisement intended for healthcare professionals Oxford Academic Journals Books …