Background Intranasal esketamine has received regulatory approvals for the treatment of
depression. Recently a large trial of repeated dose racemic ketamine also demonstrated …

The United States is entering its fourth decade of the opioid epidemic with no clear end in
sight. At the center of the epidemic is an increase in opioid use disorder (OUD), a complex …

Background Developing biological based approaches for preventing suicide has become a
priority. In recent years, there has been a surge in studies investigating the role of the …

Objective Non-tricyclic antidepressants (non-TCAs) work by preventing the intake of
norepinephrine and serotonin. Therefore, the aim of this study was to identify a potent non …

Ketamine, initially developed as a safer alternative to phencyclidine, has emerged as a
groundbreaking treatment in psychiatric practice. It gained popularity after its approval by the …

[Methods] We evaluated changes in the gene expression of the metabotropic glutamate
receptor 5 (mGluR5) and its scaffolding proteins Homer1a and p11 in the dorsolateral …

What Is the Issue?• Many drug treatments are available for depression, but 22% of people in
Canada with the condition have treatment-resistant depression (TRD). For people with TRD …

A Depressão Maior (DM) é uma doença crônica e incapacitante, que apresenta elevadas
taxas de resistência ao tratamento. Sua neurobiologia é complexa, e a exposição ao …

A depressão, um dos transtornos mentais mais prevalentes em escala global, tem suscitado
um interesse substancial na comunidade acadêmica e clínica. No entanto, sua associação …

Background: Suicide is a significant public health concern, and effective treatments are
needed to alleviate suicide ideation (SI) in high-risk individuals. Ketamine has demonstrated …