The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …

Although weight gain is a serious but variable adverse effect of antipsychotics that has
genetic underpinnings, a comprehensive meta-analysis of pharmacogenetics of …

Abstract Second-generation antipsychotics (SGAs), such as risperidone, clozapine and
olanzapine, are the most common drug treatments for schizophrenia. SGAs presented an …

Antipsychotic medications are critical to child and adolescent psychiatry, from the
stabilization of psychotic disorders like schizophrenia, bipolar disorder, and psychotic …

Importance of the field: Antipsychotic drug is the mainstay of treatment for schizophrenia,
and there are large inter-individual differences in clinical response and side effects …

Prescriptions for second-generation antipsychotics (SGAs) have surpassed those for first-
generation agents in the treatment of schizophrenia and bipolar disorder. While SGAs have …

Objectives: The presence of metabolic abnormalities is an important risk factor for
cardiovascular disease and diabetes. There are limited data on the prevalence of the …

The prevalence of overweight and obesity is higher in people with mental illness than in the
general population. Body weight is tightly regulated by a complex system involving the …

Psychiatric pharmacotherapy with olanzapine is commonplace. We investigated the
influence of CYP1A2* 1F (− 163A, rs762551) and serotonergic polymorphisms on …

Aims: This study aims to test for possible associations between the gene coding for the 5-
HT2C receptor and antipsychotic-induced weight gain. Materials & methods: Four HTR2C …