MicroRNA-383: A tumor suppressor miRNA in human cancer

A Jafarzadeh, M Noori, S Sarrafzadeh… - Frontiers in cell and …, 2022 - frontiersin.org
Downregulated expression of anti-tumor miR-383 has been found in many kinds of cancer.
MiR-383 family members can directly target the 3′-untranslated region (3′-UTR) of the …

The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance in non-small cell lung cancer through PI3K/AKT signaling

D Wu, T Zhang, Y Liu, S Deng, R Han, T Liu, J Li… - Cell death & …, 2019 - nature.com
Abstract Paired-box 6 (PAX6) is an important transcription factor required for the function of
human neuroectodermal epithelial tissues. Previous studies have suggested that it is also …

LncRNA DUXAP10 upregulation and the hedgehog pathway activation are critically involved in chronic cadmium exposure-induced cancer stem cell-like property

HP Lin, Z Wang, C Yang - Toxicological Sciences, 2021 - academic.oup.com
Cadmium (Cd) is a well-known lung carcinogen. However, the mechanism of Cd
carcinogenesis remains to be clearly defined. Cd has been shown to act as a weak …

LncRNA SNHG17 promotes the progression of oral squamous cell carcinoma by modulating miR-375/PAX6 axis

F Tong, J Guo, Z Miao, Z Li - Cancer Biomarkers, 2021 - content.iospress.com
BACKGROUND: The prognosis of patients with recurrent and/or metastatic oral squamous
cell carcinoma (OSCC) remains poor, and its incidence is especially high in developing …

Investigating the mechanism by which SMAD3 induces PAX6 transcription to promote the development of non-small cell lung cancer

Z Qian, Q Zhang, Y Hu, T Zhang, J Li, Z Liu, H Zheng… - Respiratory …, 2018 - Springer
Background This study investigated the function of SMAD3 (SMAD family member 3) in
regulating PAX6 (paired box 6) in non-small cell lung cancer. Methods First, qRT-PCR was …

Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts

MM Pallotta, M Di Nardo, A Musio - Cells, 2024 - mdpi.com
Cohesin is a highly conserved ring-shaped complex involved in topologically embracing
chromatids, gene expression regulation, genome compartmentalization, and genome …

Profilin 2 isoform expression is associated with lung metastasis of colorectal cancer according to a comprehensive gene expression study using a mouse model

N Toyota, M Tsuruta, Y Tajima… - Oncology …, 2024 - spandidos-publications.com
Lung metastasis is the second most common type of metastasis in colorectal cancer.
Specific treatments for lung metastasis have not been developed since the underlying …

Downregulated pancreatic beta cell genes indicate poor prognosis in patients with pancreatic neuroendocrine neoplasms

A Kudo, K Akahoshi, S Ito, T Akashi, S Shimada… - Annals of …, 2020 - journals.lww.com
Objective: To predict metachronous liver metastasis after pancreatectomy for pancreatic
neuroendocrine neoplasms (Pan-NENs). Summary of Background Data: Liver metastasis …

[HTML][HTML] Role of PAX6, TRPA1, BCL11B, MCOLN2, CUX1, EMX1 in colorectal cancer and osteosarcoma

J Zhang, Q Gao, S Hou, X Chi, M Zheng, Q Zhang… - Medicine, 2024 - journals.lww.com
Colorectal cancer is a cancer that arises from the abnormal growth of cells in the colon or
rectum. Osteosarcoma (OS) is a common primary bone tumor with high degree of …

PAX6 is frequently expressed in ependymal tumours and associated with prognostic relevant subgroups

J Tabasaran, M Schuhmann, M Ebinger… - Journal of Clinical …, 2022 - jcp.bmj.com
Aims An ependymoma shows divergent morphological and molecular features depending
on their location. The paired box 6 (PAX6) transcription factor is a putative tumour …