The brain is a highly energy-demanding organ and requires bioenergetic adaptability to
balance normal activity with pathophysiological fuelling of spontaneous recurrent seizures …

The blood–brain barrier (BBB) is a dynamic platform for exchange of substances between
the blood and the brain parenchyma, and it is an essential functional gatekeeper for the …

Lower brain glucose metabolism is present before the onset of clinically measurable
cognitive decline in two groups of people at risk of Alzheimer's disease---carriers of …

Background Alzheimer's disease (AD) is characterized by early and region-specific declines
in cerebral glucose metabolism. Ketone bodies are produced by the body during glucose …

Coconut, Cocos nucifera L., is a tree that is cultivated to provide a large number of products,
although it is mainly grown for its nutritional and medicinal values. Coconut oil, derived from …

Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

The ketogenic diet has been in clinical use for over 80 years, primarily for the symptomatic
treatment of epilepsy. A recent clinical study has raised the possibility that exposure to the …

The ketogenic diet (KD) is a broadly effective treatment for medically refractory epilepsy.
Despite nearly a century of use, the mechanisms underlying its clinical efficacy remain …

Fasting has been used to control epilepsy since antiquity, but the mechanism of coupling
between metabolic state and excitatory neurotransmission remains unknown. Previous work …

The ketogenic diet, a high fat, adequate protein, low carbohydrate diet, has, during the past
decade, had a resurgence of interest for the treatment of difficult-to-control seizures in …