Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
shaping cancer immunosurveillance and response to immunotherapy. Our understanding of …

Outer membrane vesicles: biogenesis, functions, and issues

R Juodeikis, SR Carding - Microbiology and Molecular Biology …, 2022 - Am Soc Microbiol
This review focuses on nonlytic outer membrane vesicles (OMVs), a subtype of bacterial
extracellular vesicles (BEVs) produced by Gram-negative organisms focusing on the …

Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and …

M Bielaszewska, C Rüter, A Bauwens, L Greune… - PLoS …, 2017 - journals.plos.org
Outer membrane vesicles (OMVs) are important tools in bacterial virulence but their role in
the pathogenesis of infections caused by enterohemorrhagic Escherichia coli (EHEC) O157 …

Collateral damage: insights into bacterial mechanisms that predispose host cells to cancer

A Gagnaire, B Nadel, D Raoult, J Neefjes… - Nature Reviews …, 2017 - nature.com
Infections are estimated to contribute to 20% of all human tumours. Viruses are known to
induce cell transformation, but evidence has also linked bacteria, such as Helicobacter …

The effect of the intratumoral microbiome on tumor occurrence, progression, prognosis and treatment

F Gao, B Yu, B Rao, Y Sun, J Yu, D Wang… - Frontiers in …, 2022 - frontiersin.org
In the past few decades, great progress has been achieved in the understanding of
microbiome-cancer interactions. However, most of the studies have focused on the gut …

The intratumoral microbiota: friend or foe?

V Ferrari, M Rescigno - Trends in cancer, 2023 - cell.com
The intratumoral microbiota has been recently identified as important in cancer evasion
strategies. It can induce DNA damage, favor the epithelial–mesenchymal transition …

Xenobiotics formed during food processing: Their relation with the intestinal microbiota and colorectal cancer

AM Nogacka, M Gómez-Martín, A Suárez… - International journal of …, 2019 - mdpi.com
The colonic epithelium is exposed to a mixture of compounds through diet, among which
some are procarcinogens, whereas others have a protective effect. Therefore, the net impact …

Genotoxins: The Mechanistic Links between Escherichia coli and Colorectal Cancer

Y Wang, K Fu - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a leading cause of cancer-related mortality
worldwide, and its incidence is steadily rising in developing areas. Bacterial pathogens from …

When bacteria target the nucleus: the emerging family of nucleomodulins

H Bierne, P Cossart - Cellular microbiology, 2012 - Wiley Online Library
The nucleus, at the heart of the eukaryotic cell, hosts and protects the genetic material,
governs gene expression and regulates the whole cell physiology, including cell division. A …

Bacterial genotoxins: merging the DNA damage response into infection biology

F Grasso, T Frisan - Biomolecules, 2015 - mdpi.com
Bacterial genotoxins are unique among bacterial toxins as their molecular target is DNA.
The consequence of intoxication or infection is induction of DNA breaks that, if not properly …