As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Highlights•More than 40 loci of interest have been associated with the risk of developing
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …

Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Microglia have emerged as important players in brain aging and pathology. To understand
how genetic risk for neurological and psychiatric disorders is related to microglial function …

Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost
importance. Although genetic studies have identified AD-associated SNPs in APOE and …

Background Alzheimer's disease is one of the most heritable diseases in elderly people and
the most common type of dementia. In addition to the major genetic determinant of …

Importance The association between peripheral inflammatory biomarkers and Alzheimer
disease (AD) is not consistent in the literature. It is possible that chronic inflammation, rather …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …