The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …

Ubiquitin modification plays important roles in many cellular processes that are fundamental
for vertebrate embryo development, such as cell division, differentiation, and migration …

The accurate expression of postsynaptic AMPA receptors (AMPARs) is critical for information
processing in the brain, and ubiquitination is a key regulator for this biological process …

Summary Sonic Hedgehog (Shh) signaling plays crucial roles in patterning the ventral
neural tube, which is transformed into opposing gradients of repressor and activator forms of …

Alzheimer's disease (AD) is one of the most common neurodegeneration diseases caused
by multiple factors. The mechanistic insight of AD remains limited. To disclose molecular …

Leukodystrophies are a heterogeneous group of rare inherited disorders that mostly involve
the white matter of the CNS. These conditions are characterized by primary glial cell and …

Noradrenaline belongs to the monoamine system and is involved in cognition and emotional
behaviors. Phox2a and Phox2b play essential but non-redundant roles during development …

TDP43 pathology is seen in a large majority of amyotrophic lateral sclerosis (ALS) cases,
suggesting a central pathogenic role of this regulatory protein. Clarifying the molecular …

Abstract ZC4H2 encodes a C4H2 type zinc-finger nuclear factor, the mutation of which has
been associated with disorders with various clinical phenotypes in human, including …

STAT1 is a master regulator that orchestrates type 1 and 2 interferon (IFN)-induced IFN-
stimulated gene (ISG) expression. The mechanisms by which STAT1 is phosphorylated and …