Diclofenac: an update on its mechanism of action and safety profile
TJ Gan - Current medical research and opinion, 2010 - Taylor & Francis
Background: Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory
drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been …
drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been …
Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
JE Weder, CT Dillon, TW Hambley, BJ Kennedy… - Coordination Chemistry …, 2002 - Elsevier
The proposed curative properties of Cu-based non-steroidal anti-inflammatory drugs
(NSAIDs) have led to the development of numerous Cu (II) complexes of NSAIDs with …
(NSAIDs) have led to the development of numerous Cu (II) complexes of NSAIDs with …
[HTML][HTML] In situ click chemistry generation of cyclooxygenase-2 inhibitors
Cyclooxygenase-2 isozyme is a promising anti-inflammatory drug target, and
overexpression of this enzyme is also associated with several cancers and …
overexpression of this enzyme is also associated with several cancers and …
Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic
TD Warner, JA Mitchell - The FASEB journal, 2004 - Wiley Online Library
The beneficial actions of nonsteroidal anti‐inflammatory drugs (NSAIDs) have been linked to
their ability to inhibit inducible COX‐2 at sites of inflammation, and their side effects (eg …
their ability to inhibit inducible COX‐2 at sites of inflammation, and their side effects (eg …
[PDF][PDF] Anti-inflammatory and side effects of cyclo-oxygenase inhibitors
H Suleyman, B Demircan, Y Karagoz - Pharmacological reports, 2007 - academia.edu
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly used drugs in
inflammatory diseases, since they are effective in management of pain, fever, redness …
inflammatory diseases, since they are effective in management of pain, fever, redness …
Cyclooxygenase-2—10 years later
B Hinz, K Brune - Journal of pharmacology and experimental …, 2002 - ASPET
The enzyme cyclooxygenase (COX) catalyzes the first step of the synthesis of prostanoids. In
the early 1990s, COX was demonstrated to exist as two distinct isoforms. COX-1 is …
the early 1990s, COX was demonstrated to exist as two distinct isoforms. COX-1 is …
[HTML][HTML] Cyclooxygenase-2 in endometriosis
ZZ Lai, HL Yang, SY Ha, KK Chang, J Mei… - … journal of biological …, 2019 - ncbi.nlm.nih.gov
Endometriosis (EMS) is the most common gynecological disease in women of reproductive
age, and it is associated with chronic pelvic pain, dyspareunia and infertility. As a …
age, and it is associated with chronic pelvic pain, dyspareunia and infertility. As a …
Role of nitric oxide and prostacyclin as vasoactive hormones released by the endothelium
JA Mitchell, F Ali, L Bailey, L Moreno… - Experimental …, 2008 - Wiley Online Library
The endothelium lines the luminal surface of every blood vessel, allowing it contact with
circulating blood elements, as well as the underlying vascular smooth muscle layer. In …
circulating blood elements, as well as the underlying vascular smooth muscle layer. In …
Pathophysiological roles of cyclooxygenases and prostaglandins in the central nervous system
T Yagami, H Koma, Y Yamamoto - Molecular neurobiology, 2016 - Springer
Cyclooxygenases (COXs) oxidize arachidonic acid to prostaglandin (PG) G 2 and H 2
followed by PG synthases that generates PGs and thromboxane (TX) A 2. COXs are divided …
followed by PG synthases that generates PGs and thromboxane (TX) A 2. COXs are divided …
The TRPA1 channel in inflammatory and neuropathic pain and migraine
R Nassini, S Materazzi, S Benemei… - Reviews of Physiology …, 2014 - Springer
The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized to a subpopulation of primary sensory neurons of the …
channels, is primarily localized to a subpopulation of primary sensory neurons of the …