As a promising alternative platform for cellular immunotherapy, natural killer cells (NK) have
recently gained attention as an important type of innate immune regulatory cell. NK cells can …

Natural killer (NK) cells are potent immune effector cells that can respond to infection and
cancer, as well as allowing maternal adaptation to pregnancy. In response to malignant …

NK1. 1 and its human homolog CD161 are expressed on NK cells, subsets of CD4+ and
CD8+ T cells, and NKT cells. While the expression of NK1. 1 is thought to be inhibitory to NK …

Membrane lipids seem to be organized and not randomly distributed in the cell membrane.
In particular, sphingolipids seem to interact with cholesterol in the outer leaflet of the cell …

Abstract Multiple Sclerosis (MuS) is a complex multifactorial neuropathology, resulting in
heterogeneous clinical presentation. A very active MuS research field concerns the …

Sphingomyelin (SM) can be converted into ceramide (Cer) by neutral sphingomyelinase
(NSM) and acid sphingomyelinase (ASM). Cer is a second messenger of lipids and can …

The success of immune checkpoint therapy in cancer has changed our way of thinking,
promoting the design of future cancer treatments that places the immune system at the …

Sphingolipids are a class of bioactive lipids, which are key modulators of an increasing
number of physiologic and pathophysiologic processes that include cell cycle, apoptosis …

Introduction Preeclampsia is a multisystemic, pregnancy-specific disorder united by new-
onset hypertension but with considerable variation in clinical manifestation, onset, and …

CD161 is a C-type lectin-like receptor expressed on human natural killer (NK) cells and
subsets of T cells. CD161 has been described as an inhibitory receptor that regulates NK …