Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach
Pulmonary arterial hypertension (PAH) is responsible for the premature death mainly
because of progressive and severe heart failure. This disease is characterized by increased …
because of progressive and severe heart failure. This disease is characterized by increased …
[HTML][HTML] Two decades with dimorphic chloride intracellular channels (CLICs)
H Singh - FEBS letters, 2010 - Elsevier
Plasma membrane channels have been extensively studied, and their physiological roles
are well established. In contrast, relatively little information is available about intracellular …
are well established. In contrast, relatively little information is available about intracellular …
Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline
P Caruso, MR MacLean, R Khanin… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to
control protein production through binding “seed” sequences within a target mRNA. Each …
control protein production through binding “seed” sequences within a target mRNA. Each …
BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress
A Hishiya, T Kitazawa, S Takayama - Circulation research, 2010 - Am Heart Assoc
Rationale: A homozygous disruption or genetic mutation of the bag 3 gene, a member of the
Bcl-2–associated athanogene (BAG) family proteins, causes cardiomyopathy and …
Bcl-2–associated athanogene (BAG) family proteins, causes cardiomyopathy and …
Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension
VB Abdul-Salam, J Wharton, J Cupitt, M Berryman… - Circulation, 2010 - Am Heart Assoc
Background—Pulmonary arterial hypertension is a disorder of vascular remodeling causing
increased resistance to pulmonary blood flow. The expression of proteins in lungs from …
increased resistance to pulmonary blood flow. The expression of proteins in lungs from …
Effects of lovastatin on breast cancer cells: a proteo-metabonomic study
J Klawitter, T Shokati, V Moll, U Christians… - Breast cancer …, 2010 - Springer
Introduction Statins are cholesterol-lowering drugs with pleiotropic activities including
inhibition of isoprenylation and reduction of signals driving cell proliferation and survival …
inhibition of isoprenylation and reduction of signals driving cell proliferation and survival …
Fhl-1, a new key protein in pulmonary hypertension
G Kwapiszewska, M Wygrecka, LM Marsh, S Schmitt… - Circulation, 2008 - Am Heart Assoc
Background—Pulmonary hypertension (PH) is a severe disease with a poor prognosis.
Different forms of PH are characterized by pronounced vascular remodeling, resulting in …
Different forms of PH are characterized by pronounced vascular remodeling, resulting in …
Oxidation promotes insertion of the CLIC1 chloride intracellular channel into the membrane
SC Goodchild, MW Howell, NM Cordina… - European biophysics …, 2009 - Springer
Members of the chloride intracellular channel (CLIC) family exist primarily as soluble
proteins but can also auto-insert into cellular membranes to form ion channels. While little is …
proteins but can also auto-insert into cellular membranes to form ion channels. While little is …
Integrated bioinformatic analysis reveals YWHAB as a novel diagnostic biomarker for idiopathic pulmonary arterial hypertension
T Wang, X Zheng, R Li, X Liu, J Wu… - Journal of cellular …, 2019 - Wiley Online Library
Idiopathic pulmonary arterial hypertension (IPAH) is a severe cardiovascular disease that is
a serious threat to human life. However, the specific diagnostic biomarkers have not been …
a serious threat to human life. However, the specific diagnostic biomarkers have not been …
The proteome of hypobaric induced hypoxic lung: insights from temporal proteomic profiling for biomarker discovery
Y Ahmad, NK Sharma, MF Ahmad, M Sharma, I Garg… - Scientific reports, 2015 - nature.com
Exposure to high altitude induces physiological responses due to hypoxia. Lungs being at
the first level to face the alterations in oxygen levels are critical to counter and balance these …
the first level to face the alterations in oxygen levels are critical to counter and balance these …