Pulmonary arterial hypertension (PAH) is responsible for the premature death mainly
because of progressive and severe heart failure. This disease is characterized by increased …

Plasma membrane channels have been extensively studied, and their physiological roles
are well established. In contrast, relatively little information is available about intracellular …

Objective—MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to
control protein production through binding “seed” sequences within a target mRNA. Each …

Rationale: A homozygous disruption or genetic mutation of the bag 3 gene, a member of the
Bcl-2–associated athanogene (BAG) family proteins, causes cardiomyopathy and …

Background—Pulmonary arterial hypertension is a disorder of vascular remodeling causing
increased resistance to pulmonary blood flow. The expression of proteins in lungs from …

Introduction Statins are cholesterol-lowering drugs with pleiotropic activities including
inhibition of isoprenylation and reduction of signals driving cell proliferation and survival …

Background—Pulmonary hypertension (PH) is a severe disease with a poor prognosis.
Different forms of PH are characterized by pronounced vascular remodeling, resulting in …

Members of the chloride intracellular channel (CLIC) family exist primarily as soluble
proteins but can also auto-insert into cellular membranes to form ion channels. While little is …

Idiopathic pulmonary arterial hypertension (IPAH) is a severe cardiovascular disease that is
a serious threat to human life. However, the specific diagnostic biomarkers have not been …

Exposure to high altitude induces physiological responses due to hypoxia. Lungs being at
the first level to face the alterations in oxygen levels are critical to counter and balance these …