Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Estrogen deficiency has been considered the seminal mechanism of osteoporosis in both
women and men, but epidemiological evidence in humans and recent mechanistic studies …

Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone
mass and microarchitectural deterioration. Here, we show that warmth exposure (34° C) …

Marrow adipocytes, collectively termed marrow adipose tissue (MAT), reside in the bone
marrow in close contact to bone cells and haematopoietic cells. Marrow adipocytes arise …

MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. In
contrast, we find that Myc haploinsufficient (Myc+/–) mice exhibit increased lifespan. They …

Leptin originates in adipocytes, including those in bone marrow, and circulates in
concentrations 20 to 90 times higher than those in the cerebrospinal fluid. It has direct …

Excess body weight due to obesity has traditionally been considered to have a positive
effect on bone; however, more recent findings suggest that bone quality is compromised …

Body weight is a principal determinant of bone density and fracture risk, and adipose tissue
mass is a major contributor to this relationship. In contrast, some recent studies have argued …

The effects of caloric restriction (CR) on the skeleton are well studied in adult rodents and
include lower cortical bone mass but higher trabecular bone volume. Much less is known …

Obesity and osteoporosis are two of the most common chronic disorders of the 21st century.
Both are accompanied by significant morbidity. The only place in the mammalian organism …