Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

Transcription factors (TFs) have a key role in controlling the gene regulatory network that
sustains explicit cell states in humans. However, an uncontrolled regulation of these genes …

Endometrioid ovarian carcinoma (EnOC) demonstrates substantial clinical and molecular
heterogeneity. Here, we report whole exome sequencing of 112 EnOC cases following …

Glioblastoma (GBM) is the most common, most aggressive and deadliest brain tumor.
Recently, remarkable progress has been made towards understanding the cellular and …

Highlights•Many members of the SOX family of transcription factors possess the capacity to
drive direct conversion to a variety of cell lineages.•We review target lineages that have …

SOX2 is a transcription factor involved in multiple stages of embryonic development. In
related reports, SOX2 was found to be abnormally expressed in tumor tissues and correlated …

Emerging evidence indicates that nuclear factor I/B (NFIB), a transcription factor required for
proper development and regulation of cellular differentiation in several tissues, also plays …

The SOX genes encode a family of more than 20 transcription factors that are critical
regulators of embryogenesis and developmental processes and, when aberrantly …

DNA hypermethylation has emerged as a molecular biomarker for the evaluation of cancer
diagnosis and prognosis. We define a methylation signature of bladder cancer and evaluate …

The embryonic development of neural crest cells and subsequent tissue differentiation are
intricately regulated by specific transcription factors. Among these, SOX10, a member of the …