Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein
Acquired resistance against antimalarial drugs has further increased the need for an
effective malaria vaccine. The current leading candidate, RTS, S, is a recombinant …
effective malaria vaccine. The current leading candidate, RTS, S, is a recombinant …
Prevalence and risk factors associated with asymptomatic malaria among school children: repeated cross-sectional surveys of school children in two ecological zones …
BA Mensah, JL Myers-Hansen, E Obeng Amoako… - BMC Public Health, 2021 - Springer
Abstract Background Asymptomatic Plasmodium infections significantly drive malaria
transmission and impact control and elimination strategies, but are largely uncharacterized …
transmission and impact control and elimination strategies, but are largely uncharacterized …
The P. falciparum CSP repeat region contains three distinct epitopes required for protection by antibodies in vivo
Y Flores-Garcia, LT Wang, M Park, B Asady… - PLoS …, 2021 - journals.plos.org
Rare and potent monoclonal antibodies (mAbs) against the Plasmodium falciparum (Pf)
circumsporozoite protein (CSP) on infective sporozoites (SPZ) preferentially bind the PfCSP …
circumsporozoite protein (CSP) on infective sporozoites (SPZ) preferentially bind the PfCSP …
First-in-human assessment of safety and immunogenicity of low and high doses of Plasmodium falciparum malaria protein 013 (FMP013) administered intramuscularly …
JN Hutter, PM Robben, C Lee, M Hamer, JE Moon… - Vaccine, 2022 - Elsevier
The global burden of malaria remains substantial. Circumsporozoite protein (CSP) has been
demonstrated to be an effective target antigen, however, improvements that offer more …
demonstrated to be an effective target antigen, however, improvements that offer more …
Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum
The most advanced P. falciparum circumsporozoite protein-based malaria vaccine, RTS,
S/AS01 (RTS, S), confers partial protection but with antibody titers that wane relatively …
S/AS01 (RTS, S), confers partial protection but with antibody titers that wane relatively …
Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts
The circumsporozoite protein (CSP) on the surface of Plasmodium falciparum sporozoites is
important for parasite development, motility, and host hepatocyte invasion. However …
important for parasite development, motility, and host hepatocyte invasion. However …
Restricted valency (NPNA)n repeats and junctional epitope-based circumsporozoite protein vaccines against Plasmodium falciparum
MD Langowski, FA Khan, S Savransky, DR Brown… - npj Vaccines, 2022 - nature.com
Abstract The Circumsporozoite Protein (CSP) of Plasmodium falciparum contains an N-
terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major …
terminal region, a conserved Region I (RI), a junctional region, 25–42 copies of major …
Subclass and avidity of circumsporozoite protein specific antibodies associate with protection status against malaria infection
KE Seaton, RL Spreng, M Abraha, M Reichartz… - npj Vaccines, 2021 - nature.com
Abstract RTS, S/AS01 is an advanced pre-erythrocytic malaria vaccine candidate with
demonstrated vaccine efficacy up to 86.7% in controlled human malaria infection (CHMI) …
demonstrated vaccine efficacy up to 86.7% in controlled human malaria infection (CHMI) …
estMOI: estimating multiplicity of infection using parasite deep sequencing data
Individuals living in endemic areas generally harbour multiple parasite strains. Multiplicity of
infection (MOI) can be an indicator of immune status and transmission intensity. It has a …
infection (MOI) can be an indicator of immune status and transmission intensity. It has a …
Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites
Abstract The current Malaria RTS, S vaccine is based on virus-like particles (VLPs)
comprising the NANP repetitive epitopes from the cicumsporozoite protein (CSP) of …
comprising the NANP repetitive epitopes from the cicumsporozoite protein (CSP) of …