[HTML][HTML] Identification and characterization of the first small molecule inhibitor of MDMX
The p53 pathway is disrupted in virtually every human tumor. In∼ 50% of human cancers,
the p53 gene is mutated, and in the remaining cancers, the pathway is dysregulated by …
the p53 gene is mutated, and in the remaining cancers, the pathway is dysregulated by …
Splicing up mdm2 for cancer proteome diversity
DR Okoro, M Rosso, J Bargonetti - Genes & Cancer, 2012 - journals.sagepub.com
Cancer cells often have high expression of Mdm2. However, in many cancers mdm2 is
alternatively spliced, with more than 40 mRNA variants identified. Many of the alternative …
alternatively spliced, with more than 40 mRNA variants identified. Many of the alternative …
Splice variants of MDM2 in oncogenesis
M Rosso, DE Okoro, J Bargonetti - Mutant p53 and MDM2 in Cancer, 2014 - Springer
Many types of human cancers overexpress MDM2 protein. A common characteristic among
these cancers is an associated increase in mdm2 splice variants. Provided here is a …
these cancers is an associated increase in mdm2 splice variants. Provided here is a …
MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells
L Gu, H Zhang, J He, J Li, M Huang, M Zhou - Oncogene, 2012 - nature.com
The MYCN gene has a critical role in determining the clinical behavior of neuroblastoma.
Although it is known that genomic amplification occurs in high-risk subsets, it remains …
Although it is known that genomic amplification occurs in high-risk subsets, it remains …
[HTML][HTML] Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator
DR Okoro, N Arva, C Gao, A Polotskaia, C Puente… - PloS one, 2013 - journals.plos.org
Human cancers over-expressing mdm2, through a T to G variation at a single nucleotide
polymorphism at position 309 (mdm2 SNP309), have functionally inactivated p53 that is not …
polymorphism at position 309 (mdm2 SNP309), have functionally inactivated p53 that is not …
Development and structural characterisation of human scFv targeting MDM2 spliced variant MDM215kDa
The murine double minute 2 (MDM2) protein is a major negative regulator of the tumour
suppressor protein p53. Under normal conditions, MDM2 constantly binds to p53 …
suppressor protein p53. Under normal conditions, MDM2 constantly binds to p53 …
Recombinant human MDM2 oncoprotein shows sequence composition selectivity for binding to both RNA and DNA
C Challen, JJ Anderson… - International …, 2012 - spandidos-publications.com
MDM2 is a 90 kDa nucleo-phosphoprotein that binds p53 and other proteins contributing to
its oncogenic properties. Its structure includes an amino proximal p53 binding site, a central …
its oncogenic properties. Its structure includes an amino proximal p53 binding site, a central …
MYCN and the p53-MDM2/MDMX-p14ARF network in neuroblastoma amd response to MDM2-p53 antagonists
LD Gamble - 2012 - theses.ncl.ac.uk
Background: MYCN-amplification is a major negative prognostic marker, occurring in 25-
30% of neuroblastomas. MYCN plays contradictory roles in promoting cell growth and …
30% of neuroblastomas. MYCN plays contradictory roles in promoting cell growth and …