Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Hedgehog (Hh) proteins regulate the development of a wide range of metazoan embryonic
and adult structures, and disruption of Hh signaling pathways results in various human …

The Hedgehog (Hh) signaling pathway is intimately linked to cell growth and differentiation,
with normal roles in embryonic pattern formation and adult tissue homeostasis and …

The transcriptional program orchestrated by Hedgehog signaling depends on the Gli family
of transcription factors. Gli proteins can be converted to either transcriptional activators or …

The Hedgehog (Hh) signaling pathway is of central importance during embryo development
in metazoans and governs a diverse array of processes including cell proliferation …

Summary The Hedgehog (Hh) pathway plays important roles during embryogenesis and
carcinogenesis. Here, we show that ablation of the mouse Suppressor of fused (Sufu), an …

A central question in Hedgehog (Hh) signaling is how evolutionarily conserved components
of the pathway might use the primary cilium in mammals but not fly. We focus on Suppressor …

Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily
conserved, recent studies indicate that fundamental differences exist between Drosophila …

In the hedgehog signaling network, mutations result in various phenotypes, including,
among others, holoprosencephaly, nevoid basal cell carcinoma syndrome, Pallister‐Hall …