A major obstacle in the treatment of acute myeloid leukemia (AML) is refractory disease or
relapse after achieving remission. The latter arises from a few therapy-resistant cells within …

The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

We report that cardiac fibroblasts (CFs) and mesenchymal progenitors are more hypoxic
than other cardiac interstitial populations, express more hypoxia-inducible factor 1α (HIF …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Immunological niches are focal sites of immune activity that can have varying
microenvironmental features. Hypoxia is a feature of physiological and pathological …

In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …

Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

The biology of haematopoietic stem cells (HSCs) has predominantly been studied under
transplantation conditions,. It has been particularly challenging to study dynamic HSC …